摘要
自20世纪80年代初幽门螺旋杆菌被发现以来,越来越多的证据表明,感染幽门螺旋杆菌可能导致胃溃疡,胃黏膜的慢性炎症,并增加患胃癌的风险。高达40%—60%的胃癌发生可以归因为幽门螺旋杆菌感染,因此抗幽门螺杆菌感染是胃癌一级预防的关键策略,特别是在高风险人群中。本文综述了幽门螺旋杆菌感染的流行病学、生物学、治疗方法以及根除幽门螺旋杆菌的胃癌预防途径。
Since Helicobacter pylori was identified in early 1980＇s, evidences accumulated reveal that infection with Helicobacterpylori could cause gastric ulcer, chronic inflammatory of gastric mucosa and increased the risk of gastric cancer. Because the risk for gastric cancer attributable to Helicobacterpylori infection is as high as 40--60%, anti-Helicobacter pylori is a critical strategy in primary prevention of gastric cancer, particularly in the high-risk population. The epidemiology, biology, therapy of Helicobacter pylori infection and gastric cancer prevention by eradication of Helicobacterpylori are reviewed in this article.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2013年第9期1575-1582,共8页
Progress in Chemistry
关键词
幽门螺旋杆菌
胃癌
胃癌前病变
预防
Helicobacterpylori
gastric cancer
precancerous gastric lesion
prevention
