摘要
目的:探讨乌司他丁对老年重症脑出血(ICH)诱导的急性胃肠损伤的影响。方法:选取急性基底节区ICH老年患者60例,按数字表法随机分为治疗组及对照组。对照组给予常规治疗;治疗组在基础治疗上加用乌司他丁60万U,静脉滴注,bid,连用7 d。检测2组治疗前及治疗后第1,3,7天血浆二胺氧化酶(DAO)及D-乳酸水平,并记录2组患者首次肠道排空时间,计算3 d肠道排空率。结果:治疗前,2组D-乳酸及DAO无差异;与对照组比较,治疗组ICH老年患者在3,7 d时D-乳酸及DAO均较对照组显著降低(P<0.01),3 d肠道排空率较对照组显著提高(P<0.05)。结论:乌司他丁可能通过降低肠黏膜的通透性,减轻肠黏膜的损伤,促进老年重症脑出血患者继发的急性胃肠损伤的恢复。
OBJECTIVE To study the effect of ulinastatin on acute bowel injury secondary to acute intracerebral hemorrhage （ICH）. METHODS Sixty elderly patients with ICH were divided randomly into two groups： ulinastatin group（U group） and control group. Patients in both groups were received conventional therapy, while in the U group, patients were injected with ulinastatin （0. 6 mU, twice one day in a week）. Endotoxin, Dlactate acid and diamineoxidase （DAO） were evaluated on before and 3, 7 d after treatment. Recorded the first time of intestine evacuation, accounted the rate of intestine evacuation in three day. RESULTS Compared with control group, the level of endotoxin, Ilactic acid and DAO were obviously decreased in U group in 3, 7 d after treatment（P〈0.01）. The rate of intestine evacuation in three days in group U was higher than that in control group（P〈0. 05）. CONCLUSION Ulinastatin may exert protective effects on patients suffering from acute gastrointes-tinal injury secondary to ICH.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2013年第19期1603-1605,共3页
Chinese Journal of Hospital Pharmacy
基金
湖北省科研基金支持项目(编号:JX6B11)
关键词
老年重症脑出血
急性胃肠损伤
乌司他丁
elderly patient with acute severe hemorrhage
acute gastrointestinal injury（AGI）
ulinastatin
