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卵泡抑素的生物学作用及其机制的研究 被引量:3

Studies on Biological Function and Mechanism of Follistatin
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摘要 卵泡抑素又名 FSH抑制蛋白 ( FSH-suppressing protein,FSP) ,是一种单链糖蛋白 ,有多种形式。作为 Activin的结合蛋白 ,它可以通过 Activin/ FSP系统来调节动物的生殖活动。近年来的实验表明 ,FSP可以通过其作用系统 ,在生殖系统以外的器官例如肝、肾、胰、骨骼、皮肤等器官和组织中起作用。FSP在细胞表面有肝素结合区 ,这有利于发挥其生物学作用。 FSP更可能是通过旁分泌或自分泌的方式与 Activin一起相互作用 ,参与体内各种生理活动的调节。 Follistatin or FSH suppressing protein(FSP),a family of single chain glucoprotein,generated by differential splicimg and proteolytic processing,has function in such system as liver pancreatic islets,kidney,bone,skin and brain,it has been suggested that FSP function in a paracrine or autocrine way by binding to the activin.The binding of FSP to the cell surface proteglycans appears to umderlie the ability of follistatin to reguiate the biological actions of activin,particularly at the local level.
出处 《动物医学进展》 CSCD 2000年第4期9-12,共4页 Progress In Veterinary Medicine
基金 国家自然科学基金资助项目!( 3 9870 577)
关键词 卵泡抑素 机制 生物学作用 Follistatin function mechanism process4
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参考文献18

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同被引文献37

  • 1刘臻,鲁双庆,肖调义,陈开键.鲫鱼基因组DNA提取方法的探讨[J].水利渔业,2004,24(6):20-22. 被引量:29
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