摘要
目的探讨术前静脉注射维拉帕米对结肠癌根治术患者氧化应激反应的影响。方法将30例行限期结肠癌根治术患者随机分为对照组和维拉帕米组,每组15例。分别测定两组患者术前(T1)、手术气腹结束后即刻(T2)及术后24 h(T3)血清ALT、AST和丙二醛(MDA)的浓度。结果与T1时相点比较,两组患者T2、T3时相点ALT和AST值均增高(P<0.05),维拉帕米组患者T2、T3时相点ALT和AST值增高幅度明显低于对照组(P<0.01);与T1时相点比较,对照组患者T2、T3时相点MDA值增高显著(P<0.05),维拉帕米组患者T2、T3时相点MDA值明显低于对照组(P<0.01)。结论术前静脉注射维拉帕米能有效减小气腹带来的氧化应激反应,有效保护肝脏等脏器的功能。
Objective To evaluate the impact of verapamil on oxidative stress reaction in patients with laparoseopic colon cancer resection. Methods 30 patients with laparoscopic colon cancer resection were randomly divided into control and verapamil groups（ n = 15 ）. The contents of serum ALT, AST and Malondialdehyde （MDA） were determined before surgery（ T1 ） and 0 or 24h after surgery （ T2 ,T3）. Resuits In both two groups, the ALT and AST values were increased at T2 and T3 time spots as compared to those at T1 （ P 〈 0.05 ）. The increased ALT and AST values at T2 and T3 in verapamil group were much lower than those in control group（ P 〈 0.01 ）. The MDA content at T2 and T3 was significantly elevated in control group as compared with that at T1 （ P 〈 0.05 ）. Compared with control group, verapamil could significantly reduce the elevated MDA level at T2 and T3 （ P 〈 0.01 ）. Conclusion The preoperative intrave- nous injection of verapamil could effectively reduce oxidative stress caused by pneumoperitoneum.
出处
《湖北科技学院学报（医学版）》
2013年第4期285-287,共3页
Journal of Hubei University of Science and Technology(Medical Sciences)
基金
深圳市科技局课题(201002021)
关键词
腹腔镜
结肠癌根治术
氧化应激
维拉帕米
Laparoscopic
Colon cancer surgery
Oxidative stress
Verapamil
