摘要
目的 探讨阿片类毒品中毒患者的急诊治疗,以便获得更好的阿片类中毒的治疗方法.方法 选取2011年2月～2012年12月中国医科大学附属盛京医院急诊治疗的50例阿片类毒品中毒患者,根据患者的临床表现采取积极有效的抢救措施,观察患者抢救成功情况、苏醒时间以及治疗后血液学的改变.结果 50例患者经积极抢救后,48例患者抢救成功,成功率为96％;2例患者出现死亡,死亡率为4％.48例患者平均苏醒时间为（43.2±4.8）min.随着昏迷时间的延长,患者的苏醒时间随之增加,不同昏迷时间的患者其苏醒时间相比,差异有统计学意义（P＜0.05）.且患者治疗后血液中的一氧化氮（NO）及一氧化氮合酶（NOS）达到分别为（76.2±16.5）mol/L和（0.61±0.10）nkat,接近正常水平,与治疗前相比差异有统计学意义（P＜0.05）.患者治疗后,心肺功能得到完全的改善,治疗后患者FVC％、、FEV1％及SpO2分别为（79.25±3.87）、（30.12±2.71）和（97.3±3.1）％,与治疗前[（50.61±3.34）、（22.89±2.31）和（82.3±2.1）％]相比,差异有统计学意义（P＜0.05）.结论 及时诊断、及早足量使用纳洛酮是成功抢救阿片类毒品中毒患者的关键.
Objective To analyze mergency treatment for opioids poisoning patients in order to find the better therapy for opioids poisoning.Methods 50 patients with opioids poisoning accepted mergency treatment from February 2011 to December 2012 in Shengiing Hospital of China Medical University were selected for observation.These patients were given positive and effective rescue measures according toclinical manifestations of patients.The condition of successful rescue,recovery time and Hematologic changes were observed.Results 96％（48/50） patients were rescued successfully and 4％（2/50） patients died.The recovery time was （43.2±4.8） min,and the recovery time was longer with prolonged coma time in these 48 patients,there was significant difference in recovery time between different coma time patients （P ＜ 0.05）.The levels of blood nitrogen monoxidum （NO） and nitricoxide synthase （NOS） of patients after treatment were （76.2±16.5） mol/L and （0.61±0.10） nkat respectively,which were closed to the normal level,compared with before treatment,the differences had statistically significant （P ＜ 0.05）.After treatment,FVC％,FEV1％ and SpO2 of lung function in the patients were （79.25±3.87）,（30.12±2.71） and （97.3±3.1）％ respectively,which were significantly different with those before treatment [（50.61 ±3.34）,（22.89±2.31） and （82.3±2.1）％,P ＜ 0.05].Conclusion Timely diagnosis and early treatment with sufficient dose of naloxone is critical for the rescue of opioids poisoning patients.
出处
《中国医药导报》
CAS
2013年第28期156-158,共3页
China Medical Herald
基金
江苏省国际合作项目(编号BZ2011034)
