摘要
血清白蛋白是疏水性分子体内输送的天然载体,具有无免疫反应、组织相容性好等特点。以血清白蛋白为材料制备的纳米药物载体载药量高、毒副作用小,并具有一定的肿瘤靶向性,是优异的药物输送载体。目前,有多个血清白蛋白纳米药物已上市或处于临床及临床前研究。总结了当前血清白蛋白纳米药物载体的主要制备方法如反溶剂法、乳化法、热凝胶法、白蛋白纳米结合技术、自组装技术、纳米喷雾干燥等以及各自的特点,讨论了常见的血清白蛋白纳米药物载体修饰手段及血清白蛋白纳米技术在药物输送领域的应用。随着研究的深入,必将有更多以血清白蛋白为载体的纳米药物问世。
Serum albumin is a natural carrier for in vivo hydrophobic molecules delivery, which is characterized by non-immunogenicity and biocompatibility. Serum albumin-based nanocarriers are outstanding carriers in drug delivery due to their high drug loading capacity, minor side effects, and solid tumor targeting properties. Currently, a great number of serum albumin-based nanodrugs have been approved or are in clinical and preclinical studies. Serum albumin nanocarriers with respects to the preparation methods including desolvation, emulsification, thermal gelation, nab-technology, self-assembly, spray-drying as well as their surface-modifications, and applications in drug delivery was summarized. More and more serum albumin-based nanocarriers will be introduced into the market as the research goes on.
出处
《功能高分子学报》
CAS
CSCD
北大核心
2013年第3期317-324,共8页
Journal of Functional Polymers
基金
国家自然科学基金(NSFC 20974096)
