摘要
目的：采用动态血压监测的方法评价阿折地平治疗青年原发性高血压的疗效。方法：选择60例青年原发性高血压患者,口服阿折地平8-16 mg,qd,治疗2个月。比较治疗前、后24 h动态血压监测的各项指标。结果：青年原发性高血压患者大多数表现为全天血压升高,且血压负荷率较高,血压昼夜节律异常（非勺型）者有51例（85.0%）。经阿折地平治疗后,患者全天的收缩压和舒张压平均值均较治疗前显著降低（P〈0.01或P〈0.05）,血压负荷率显著低于治疗前（P〈0.01）,夜间血压下降率显著高于治疗前,差异有统计学意义（P〈0.05）。只有7例（13.7%）患者血压昼夜节律由非勺型转变为勺型。治疗期间观察到的3例不良反应均较轻微。结论：青年原发性高血压患者口服阿折地平能显著降低全天血压均值和血压负荷,明显改善夜间血压下降率,对恢复血压正常昼夜节律有一定的作用,且安全性较好。
OBJECTIVE：To evaluate therapeutic efficacy of azelnidipine for essential hypertension in the youth by ambulatory blood pressure monitoring.METHODS：60 young patients with essential hypertension were collected and treated with azelnidipine 8-16 mg qd orally for 2 months.The indexes of 24 h ambulatory blood pressure monitoring were measured and compared before and after the treatment.RESULTS：The blood pressure in most young patients with essential hypertension increased all day.The loading rate of blood pressure was significantly higher than normal level.The percentage of patients with abnormal circadian rhythm of blood pressure（non-dipper）was up to 85.0%（51 cases）.The average value of systolic pressure and diastolic pressure in the whole day were decreased significantly after the treatment of azelnidipine（P0.01 or P0.05）.The loading rate of blood pressure was significantly lower than before（P0.01）;the decrease rate of blood pressure at night was significantly higher than before（P0.05）;there was statistical significance.However,there were only 7 cases（13.7%）non-dipper circadian rhythm of blood pressure changing into dippers.All adverse drug reactions were slight during treatment.CONCLUSIONS：The loading rate and average value of blood pressure of young patients with essential hypertension can be decreased markedly after oral treatment of azelnidipine.At the same time,the decrease rate of blood pressure at night can be largely improved with good safety.
出处
《中国药房》
CAS
CSCD
2013年第36期3425-3427,共3页
China Pharmacy
关键词
阿折地平
青年原发性高血压
动态血压监测
血压负荷
昼夜节律
Azelnidipine
Essential hypertension of the youth
Ambulatory blood pressure monitor
Loading rate of blood pressure
Circadian rhythm
