摘要
目的 探讨血管内皮因子 (VEGF)与鼻咽癌发生、生长及转移的关系。方法 应用LSAB免疫组织化学技术检测 5 0例鼻咽鳞状上皮癌组织中VEGF的表达。结果 鼻咽鳞状上皮癌组织中VEGF的表达明显高于鼻咽慢性炎症组织组 (P <0 0 5 ) ,在鼻咽癌组织中 ,Ⅲ ,Ⅳ期患者明显高于Ⅰ ,Ⅱ期 ,而有颈部淋巴结转移组又明显高于无颈部淋巴结转移组 (P <0 0 5 )。结论 VEGF可作为判断鼻咽癌的发生。
Objective To study the relationship between expression vascular endothelial growth factor (VEGF) and occurrence, growth and the metastasis of nasopharyngeal carcinoma (NPC).Methods Immunostaining for VEGF expression was carried out in 50 cases of nasopharyngeal squamous epithelial carcinoma.Results Expression of VEGF was significantly higher in nasopharyngeal squamous epithelial carcinoma than in chronic inflammatory nasopharyngeal tissue ( P <0 05). There was also significant difference in VEGF expression between Ⅲ or Ⅳ stage cases and Ⅰ or Ⅱ stage cases ( P <0 05). Conclusion Expression of VEGF can be used as an clinical indicator for identifying occurrence and metastasis of NPC as well as for predicting prognosis.
出处
《广东医学》
CAS
CSCD
2000年第11期932-933,共2页
Guangdong Medical Journal
关键词
鼻咽肿瘤
血管内皮生长因子
生物学行为
Nasopharyneal neoplasms
Carcinoma
Vascular endothelial growth factor(VEGF)
