摘要
目的探讨联合应用安宫降压丸治疗初发难治性高血压的临床疗效。方法选取2010年1月—2012年1月在北京中医药大学附属护国寺中医院住院和门、急诊收治的初发难治性高血压患者50例,采用随机数字表法将患者随机分成对照组25例和治疗组25例。对照组采用标准抗高血压治疗和安慰剂,治疗组在标准抗高血压治疗基础上联合应用安宫降压丸,1丸/次,2次/d。观察两组治疗效果,动态血压变化情况,头晕、头痛、心悸、失眠症状治疗效果。结果对照组显效0例,有效2例,无效23例;治疗组显效2例,有效6例,无效17例,两组治疗效果比较,差异有统计学意义(u=-2.174,P=0.0318)。两组治疗前24 h平均收缩压(24 hSBP)、24 h平均舒张压(24hDBP)、白昼收缩压(dSBP)、白昼舒张压(dDBP)、夜间收缩压(nSBP)、夜间舒张压(nDBP)比较,差异均无统计学意义(P>0.05);治疗后治疗组以上指标较对照组均降低,差异有统计学意义(P<0.05)。两组头晕治疗效果比较,差异有统计学意义(u=-2.3293,P=0.0198);两组头痛、心悸、失眠治疗效果比较,差异均无统计学意义(u值分别为-1.9404、-1.8516、-0.5774,P值分别为0.0523、0.0641、0.5637)。结论联合应用安宫降压丸治疗高血压与单纯西药降压比较,其降压过程更为平稳,症状缓解更明显,疗效满意,适合于初发难治性高血压患者。
Objective To discuss the curative effects of combined use of Angong Jiangya pills for refractory hyperten- sion treatment. Methods From January 2010 to January 2012, a total of 50 patients with refractory hypertension were treated in out - patient department, emergency department and ward of Beijing university of chinese medicine affiliated huguosi chinese med- icine hospital, the patients were divided into treatment group and control group by random number table method, 25 cases in each group. Control group were treated with standard antihypertensive therapy and placebos, treatment group were treated with standard antihypertensive therapy combined with Angong Jiangya pills, one pill per time, 2 times/d. The treatment effect for dizziness, headache, heart palpitations, insomnia, and the dynamic changes in blood pressure were compared between the two groups. Results In control group, the numbers of remarkable effect, effect and inefficacy after treatment were 0, 2 and 23 cases respectively ; in treatment group, the numbers of remarkable effect, effect and inefficacy after treatment were 2, 6 and 17 cases re- spectively. There was statistical significance between the two groups in curative effects （ u = 2. 174, P = 2. 174 ） . Before treat- ment, there was no significant difference in 24 h average systolic blood pressure （24 hSBP）, 24 h average diastolic blood pres- sure （24 hDBP） , day systolic blood pressure （dSBP） , day diastolic blood pressure （dDBP）, night systolic blood pressure （nSBP） and night diastolic blood pressure （nDBP） between two groups （ P 〉 0. 05 ） ; after treatment, the above indexes in treatment group were significantly lower than those in the control group （ P 〈 0. 05 ） . There was statistical significance between the two groups in dizziness symptom curative effects （ u = 2. 3293, P = 2. 3293 ） ; there were no statistically significant differences in curative effects on headache, heart palpitations and insomnia （u values were 1. 9404, 1.8516, 1. 8516, respectively, P val- ues were 0. 0523, 0. 0641,0. 5637, respectively） . Conclusion The clinical efficacy of Angong Jiangya Pills combination thera- py for refractory hypertension is superior to western medicine treatment alone, combination therapy can reduce blood pressure more smoothly, relieve symptoms more remarkbly, and obtain satisfactory curative effect, Angong Jiangya pills combination therapy is applicable to patients with refractory hypertension.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第24期2890-2892,共3页
Chinese General Practice
关键词
高血压
安宫降压丸
治疗结果
症状
Hypertension
Angong Jiangya pills
Treatment outcome
Symptoms
