摘要
目的 探讨肺表面活性物质 (PS)替代治疗对支气管肺发育不良 (BPD)发生率的影响。 方法 采用单剂 Exosurf气管内治疗 2 5例新生儿呼吸窘迫综合症 (NRDS)患儿 ,并与同期未用 PS治疗的 2 5例 NRDS患儿进行前瞻性非随机对照研究 ,统计 BPD的发生情况。 结果 PS运用组机械通气及氧疗时间较未用 PS组明显缩短 ,机械通气的天数由 (13± 9) d下降为 (6± 4) d,氧疗天数由(2 1± 9) d下降为 (9± 6 ) d,差异有显著性意义。BPD的发生率由 40 %下降至 2 0 % ,差异无显著性意义。 结论 PS治疗 NRDS患儿能缩短机械通气的时间及氧疗天数 ,但是否减少 BPD的发生率 。
Obiective To explore the effect of pulmanory surfactant on the incidence of bronchopulmonary dysplasia. Methods In a case control study, 25 newborns with NRDS were treated with Exosurf. At the same time, other 25 newbons with NRDS were served as control. The incidence of BPD in two groups was compared. Results The duration of mechanical ventilation and oxygen therapy was shortened in the group treated with PS (13 2±9) days vs (6±4) days, (21±9) days vs (9.3±6) days, respectively The incidence of BPD was decreased from 40% to 20%. Conclusion The duration of mechanical ventilation and oxygen therapy can be shortened in the newbons of NRDS treated with PS, but the decreasing of the incidence of BPD were not confirmed.
出处
《中华围产医学杂志》
CAS
2000年第4期214-215,共2页
Chinese Journal of Perinatal Medicine
关键词
肺表面活性剂
支气管肺发育不良
替代治疗
Pulmonary surfactantss
Infant, newborn
Bronchopulmonary dysplasiaD
