摘要
目的了解2011年我国不同地区15所医院临床分离不动杆菌属细菌分布及其耐药性。方法共收集15所教学医院临床分离的6 723株不动杆菌属细菌,其中鲍曼不动杆菌5 958株(88.6%)。按照统一方案,采用纸片扩散法进行药敏试验,结果按CLSI 2012年版标准判读,采用WHONET5.6软件进行数据分析。结果 6 723株不动杆菌属细菌中,分离自住院患者6 003株(89.3%),分离自门急诊患者720株(10.7%)。33.9%不动杆菌属细菌分离自ICU,其次为内科病房(29.3%)。鲍曼不动杆菌对头孢哌酮-舒巴坦和米诺环素的耐药率最低,分别为43.4%和31.1%,其次为阿米卡星(52.4%);对亚胺培南和美罗培南的耐药率分别为65.2%和66.2%。不同医院、不同科室分离的细菌对抗菌药物的耐药率不同。科室中以ICU分离耐药菌株耐药率最高。出现较多多重耐药(51.7%,3 081/5 958)和泛耐药(27.4%,1 635/5 958)株。结论鲍曼不动杆菌是不动杆菌属中最常见的菌种,该菌除对米诺环素和头孢哌酮-舒巴坦外的大多数抗菌药物的耐药率在60.0%以上,且检出率呈逐年增长的趋势。不同地区医院、不同科室分离的鲍曼不动杆菌对抗菌药物的耐药率相差较大。
Objective To investigate the antimicrobial resist ance of A. baumanii strains isolated from 15 hospital （13 general hospitals and 2 Children＇ s hospitals） in severl re gions across China during 2011. Methods A total of 6 723 clinical isolates of Acinetobacter were collected from 15 teaching hospitals in China, most of which were A. bauma- nii （5 958, 88.6%）. Antimicrobial susceptibility testing was carried out by means of Kirby-Bauer method according to a unified protocol. The data were analyzed by WHONET 5.6 software according to CLSI 2012 breakpoints. Results A. baumanii isolates showed the lowest resistant rates to cefoperazone-sulbactam and minocycline （43.4% and 31.1%, respectively）. The resistant rates to other antimicrobial agents were higher than 52.4%. The resistant rates to imipenem and meropenem were 65.2% and 66.2%, respectively. The antimicrobial resistance pattern varied in different hospitals across China. The resistance of A. baumanii varied from one department to another, especially higher in intensive care units. A number of pandrug-resistant （PDR） （27.4%, 1 635/5 958） and multidrug- resistant （MDR） A. baumanii strains （51.7%, 3 081/5 958） were identified. Conclusions A. baumanii is the most popular pathogenic species of Acinetobacter. The prevalence of antibiotic resistant A. baumanii strains is still increasing. More than 60% of the collected isolates during 2011 were resistant to most of antimicrobial agents tested except cefoperazone-sulbactam and minocycline, which showed good in vitro activity against A. baumanii. The resistance of A. baumanii varies greatly with hospital and department.
出处
《中国感染与化疗杂志》
CAS
北大核心
2013年第5期342-348,共7页
Chinese Journal of Infection and Chemotherapy
关键词
鲍曼不动杆菌
多重耐药
抗菌药物
Acinetobacter baumannii
multidrug-resistant
antimicrobial agents
