摘要
目的探讨清热化湿中药联合高强度聚焦超声（HIFU ）治疗晚期胰腺癌的临床疗效。方法86例晚期胰腺癌患者中有18例进行了2～3次HIFU治疗，其余68例仅接受了1次HIFU治疗，伴肝转移的53例患者中有8例同时进行了肝转移灶的HIFU消融治疗。患者HIFU治疗前后和随访期间均给予清热化湿为主的中药治疗。结果治疗后1个月HIFU辐照病灶完全缓解（CR）0例，部分缓解（PR）8例（9．3％），稳定（SD）64例（74．4％），进展（PD）14例（16．3％）。全组患者中位生存时间6个月，半年和1年生存率分别是52．0％、11．4％。73例治疗前糖类抗原199（CA199）升高的患者，治疗后有12例下降，36例治疗前糖类抗原242（CA242）升高的患者治疗后有15例下降。所有病例治疗后疼痛缓解有效率为70．9％（61/86）。结论清热化湿中药联合HIFU治疗是晚期胰腺癌有效的治疗方法。
Objective To evaluate the clinical efficacy of Qingrehuashi herbal formula combined with high intensity focused ul-trasound（HIFU ） in the treatment of advanced pancreatic cancer .Methods 86 patients with pancreatic cancer （22 case of III stage and 64 case of IV stage） were included in this study .18 cases were performed the HIFU therapy for 2-3 times .Other 68 cases re-ceived once HIFU therapy ,among 53 cases of liver metastasis ,8 cases were simultaneously conducted HIFU ablation therapy on liv-er metastasis .The patients were given Chinese medicines dominated by Qingrehuashi before and after HIFU therapy and during fol-low up period .Results The single evaluation on HIFU irradiation cases after 1 month：complete remision（CR） in 0 case ,partial re-mission（PR） in 8 cases（9 .3% ） ,stable disease（SD in 64 cases（74 .4% ） and progress disease（PD） in 14 cases（16 .3% ） .The median survival rate of 1 year and half a year was 52 .0% and 11 .4% .Among 73 cases of increased CA199 before treatment ,CA199 after treatment was decreased in 12 cases .Among 36 cases of increased CA242 before treatment ,CA242 after treatment was decreased in 15 cases .The effective rate of analgesic relief in all the cases was 70 .9% （62/86） .Conclusion The integrated therapy of Qingre-huashi herbal formula and HIFU is an effective method for treating advanced pancreatic cancer .
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第27期3231-3233,共3页
Chongqing medicine
基金
上海市科委中医引导科技资助项目(13401907100)
关键词
超声学
中草药
胰腺肿瘤
Ultrasonics
drugs, Chinese herbal
pancreatic neoplasms
