摘要
目的客观评价鼓室注射曲安奈德联合盐酸氨溴索治疗分泌性中耳炎(SOM)的疗效和安全性。方法通过检索PubMed、Embase、中国期刊全文数据库、万方、维普数据库,收集关于鼓室注射曲安奈德联合盐酸氨溴索治疗SOM的相关文献。严格制订纳入和排除标准后对相关文献进行筛选,对纳入的文献进行严格的质量评价和数据提取,用RevMan5.2软件进行Meta分析。结果 5个随机对照研究(RCT)共615耳纳入研究。在5个对照研究中,治疗组(鼓室注射曲安奈德+盐酸氨溴索)的疗效和对照组(鼓室注射地塞米松+盐酸氨溴索)比较:OR(95%CI)为4.25(2.71,6.66),差异有统计学意义(P<0.01);其中,2个对照研究,治疗组(鼓室注射曲安奈德+盐酸氨溴索)与对照组(鼓膜置管)的疗效及并发症比较:OR(95%CI)1.67(0.61,4.60),差异有统计学意义(P=0.32)及OR(95%CI)0.16(0.03,0.94),差异有统计学意义(P=0.04)。结论在SOM的治疗中,鼓室注射曲安奈德联合盐酸氨溴索的疗效优于地塞米松联合盐酸氨溴索;鼓室注射曲安奈德联合盐酸氨溴索的疗效与鼓膜置管相当,但并发症发生率低于鼓膜置管。因此,鼓室注射曲安奈德联合盐酸氨溴索治疗SOM值得临床推广。
Objective To objectively evaluate the efficacy and safety of intratympanic injection of triamcinolone acetonide plus ambroxol hydrochloride in the treatment of secretory otitis media （SOM ） .Methods The related literatures on triamcinolone ace-tonide plus ambroxol hydrochloride in treating SOM were collected by retrieving from PubMed ,Embase ,CNKI ,VIP ,Wanfang data-bases .The related literatures were screened by strictly formulating the including and excluding creteria .The included literatures were performed the strict quality evaluation and the data extraction .Meta analysis was conducted by using the Review Manager 5 .2 sofeware .Results 5 randomized controlled trials （RCTs） involving 615 ears were included .In 5 RCTs ,comparing the treatment group（intratympanic injection of triamcinolone acetonide plus ambroxol hydrochloride ） and the control group（intratympanic injec-tion of dexamethasone plus ambroxol hydrochloride）：OR（95% CI）4 .25（2 .71 ,6 .66） ,P〈0 .01 ;in 2 RCTs among them ,comparing the efficacy and complications between the treatemnt group （intratympanic injection of triamcinolone acetonide plus ambroxol hydro-chloride） and the control group（myringotomy with grommet insertion）：OR（95% CI）1 .67（0 .61 ,4 .60） ,P=0 .32 ;OR（95% CI）0 .16 （0 .03 ,0 .94） ,P=0 .04 .Conclusion The intratympanic injection of triamcinolone acetonide plus ambroxol hydrochloride is superior to dexamethasone plus ambroxol hydrochloride in the effects for treating SOM .Its efficacy is correspond to that of myringotomy with grommet insertion ,but with lower occurrence rate of complications .Therefore it deserves to be clinically promoted .
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第27期3219-3221,3224,共4页
Chongqing medicine
关键词
中耳炎
伴渗出液
META分析
曲安奈德
盐酸氨溴索
otitis media with effusion
Meta-analysis
triamcinolone acetonide
ambroxol hydrochloride
