摘要
目的 胰岛素原 (PI)、真胰岛素 (TI)是否与冠心病独立相关。方法 选择经冠状动脉(冠脉 )造影术和 (或 )冠脉内超声检查确诊的冠心病患者 5 4例 ,经检查除外冠心病的患者 37例和正常对照者 2 3例 ,每例均行口服葡萄糖耐量试验 (OGTT) ;采用高度特异性和敏感性的单克隆抗体生物素 亲和素夹心放大酶联免疫分析法测定OGTT各时相PI、TI浓度。结果 冠心病组和非冠心病组OGTT各时相PI及TI水平明显高于对照组 (P <0 0 5 ) ,当校正年龄、体重指数和腰臀围比值后 ,这种统计学差异减弱或消失 ;但在冠心病组和非冠心病组之间上述指标差异均无显著性 (P >0 0 5 )。结论 PI、TI,无论空腹还是糖负荷后 ,可能均不与冠心病独立相关。
Objective Whether proinsulin(PI)and true insulin (TI) are independently related to coronary artery disease (CAD). Methods 54 patients with CAD diagnosed by coronary angiography and/or intravascular ultrasound, 37 patients without CAD by coronary angiography and/or intravascular ultrasound and 23 healthy volunteers. All subjects had oral glucose tolerance test after an overnight 14 h fast. PI and TI concentrations were detected at different phases by BA-ELISA in which PI cross -reactivity is less than 0.1%. Results Fasting and post-glucose loading PI and TI levels in both CAD and non-CAD groups significantly increased when compared with the control group ( P <0.05), after adjustment for age, body mass index and waist hip ratio, all statistically significant associations weakened or disappeared among three groups; but there was no significant difference of all the above variables between CAD group and non-CAD group ( P >0.05). Conclusions PI and TI, whether fasting or post-glucose loading, may not be independently related to CAD.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2000年第12期814-817,共4页
Chinese Journal of Internal Medicine
