摘要
目的探讨P53、P57和Ki-67在绒毛水肿及水泡状胎块中的表达及诊断价值。方法应用免疫组化EnVision方法检测18例流产水肿绒毛、23例部分性水泡状胎块及20例完全性水泡状胎块中Ki-67、P53、P57蛋白的表达情况。结果在流产水肿绒毛、部分性水泡状胎块及完全性水泡状胎块中P53阳性的表达率分别为5.6%、60.9%、80.0%;P57的阳性表达率分别为100.0%、100.0%、0;Ki-67增殖指数(PI)分别为(11.0±6.3)%、(57.2±10.8)%、(63.2±16.8)%。结论 P53的表达及Ki-67 PI对鉴别部分性水泡状胎块和流产水肿绒毛有重要价值,P57表达对鉴别完全性水泡状胎块及部分性水泡状胎块有重要价值。
Objective To explore the expression and diagnostic value of P53, P57 and Ki-67 in the villus edema and h）,datidiform. Methods Immunohistochemical EnVision method is applied to detection of 18 cases of abortion edema villi, 23 cases of sexual bullate mole and 20 cases of complete bullate mole of Ki- 67, the expression of P53 and P57 protein. Results In miscarriage edema villi, part bullate mole and completeness bullate mole of P53 positive expression rate were 5.6% , 60.9% , 80.0% respectively; P57 the positive expression rate of 100. 0%, 100. 0%, 0 respectively; Ki-67 value-added index （%）, respectively （11.0±6.3） %, （57.2±10.8） %, （63.2 ± 16.8） % respectively. Conclusion The expression of P53 and Ki-67 value-added index to identify some sex bullate mole is valuable and abortion edema villi, P57 expression to identify completeness bullate mole and some sexual bullate mole has important value.
出处
《河南科技大学学报（医学版）》
2013年第3期161-163,共3页
Journal of Henan University of Science & Technology:Medical Science
