摘要
以4-羟基-L-脯氨酸为原料合成了非对映异构体4-(4’-甲基苯磺酰胺基)-L-脯氨酸催化剂1a-b,通过IR,1H NMR和HR-MS对其结构进行了表征,并考察了其水相中对不对称Aldol反应的催化性能.结果表明,两种催化剂在水相中均能很好地催化Aldol反应,仅用5 mol%的催化剂即可得到很好的效果,产率高达93%,非对映选择性达94∶6,而对映选择性高达99%.
Two diastereomers 4- sulfonamidyl- L- proline 1 a- b have been efficiently synthesized. The catalytic activities and stereoselectivity of these organocatalysts were evaluated in the direct asymmetric Aldol reaction of various aromatic aldehydes and ke- tones. By using 5 mol% of the catalysts, the corresponding products of the aldol reaction were obtained in good yields （ up to 93% ） with excellent anti diastereoselectivity （up to 94： 6） and enantioselectivity （up to 99% ee） in water.
出处
《河南工程学院学报（自然科学版）》
2013年第3期49-54,共6页
Journal of Henan University of Engineering：Natural Science Edition
基金
河南省教育厅自然科学研究计划项目(2011B150005)
河南工程学院博士基金(D09002)
