摘要
目的分析新生儿重症吸人性肺炎应用地塞米松联合氨溴索注射液治疗的临床疗效，为该病的临床诊治提供经验积累。方法选取我院新生儿病房于2010年3月～2012年9月收治的60例重症吸人性肺炎新生儿，利用随机数字表法进行分组，分别设为研究组和对照组，每组各30例。两组患儿均给予常规对症治疗和常规护理，其中对照组采取α-糜蛋白酶联合地塞米松进行超声雾化吸人治疗，而研究组则采取氨溴索联合地塞米松静脉滴注治疗。记录两组患儿临床症状消失时间、临床治疗总有效率和不良反应发生率，并做好对比。结果（1）研究组痊愈20例，无效1例，总有效率为96．7％，对照组痊愈13例，无效5例，总有效率为83．3％，两组之间总有效率差异具有统计学意义（P〈0．05）。（2）研究组肺部湿哕音消失时间为（3．3±1．1）d，对照组为（5．2±1．6）d，两组之间差异具有统计学意义（P〈0．05）；研究组呼吸困难消失时间为（1．7±0．5）d，对照组为（3．8±1．2）d，两组之间差异具有统计学意义（P〈0．05）。（3）研究组患儿住院时间为（7．8±1．3）d，对照组为（12．4±0．9）d，两组之间差异具有统计学意义（P〈0．05）。（4）研究组恶心1例，呕吐1例，不良反应发生率为6．67％，对照组恶心1例，呕吐1例，不良反应发生率为6．67％，两组之间差异无统计学意义（P〉0．05）。结论新生儿重症吸入性肺炎应用地塞米松联合氨溴索注射液进行治疗，相较于超声雾化治疗而言，更能促进患儿病情的好转和康复，且能缩短住院时间，取得较为满意的临床效果。
Objective To analyze the clinical effect of dexamethasone and ambroxol hydrochloride in the treatment of severe aspiration pneumonia, providing experience for clinical diagnosis and treatment. Methods 60 cases of severe aspiration pneumonia were divided into study group and control group,each group of 30 cases.Two groups were given routine symptomatic treatment and routine nursing care,the control group took the chymotrypsin combined with dexamethasone inhalation therapy,while the study group took ambroxol and dexamethasone intravenous infusion therapy.The symptoms disappeared time,clinical efficacy and adverse reactions of two groups were recorded,and making a contrast. Results （1） 20 cases of study group were cured,1 case was ineffective,the total effective rate was 96.7%, 13 cases of control group were cured,5 cases were ineffective,the total effective rate was 83.3%, the difference between the two groups was statistically significant （P 〈 0.05）.（2）Lung wet rales disappear time of study group was （3.3 ± 1.1） d,the control group was （5.2 ± 1.6）d,the difference between the two groups was statistically significant（P 〈 0.05）;breathing difficulties disappeared time of study group was （1.7 ＋ 0.5）d,the control group （3.8 ± 1.2） d,difference between the two groups was statistically significant（P 〈 0.05）.（3）The hospitalization time of study group was（7.8 ± 1.3）d,the control group was （12.4 ± 0.9） d,the difference between the two groups was statistically significant （P 〈 0.05）. （4） The incidence of adverse reaction of study group was 6.67%, the incidence of adverse reaction of the control group was 6.67%, the difference between the two groups was statistically signifieant（P 〉 0.05）. Conclusion Dexamethasone and ambroxol hydrochloridet can promote the clinical curative effect,and can shorten the time of hospitalization,obtain satisfactory clinical effect.
出处
《中国医药科学》
2013年第18期103-105,共3页
China Medicine And Pharmacy
关键词
新生儿重症吸入性肺炎
地塞米松
氨溴索
住院时间
临床疗效
Severe neonatal aspiration pneumonia
Dexamethasone
Ambroxol
Hospitalization
Clinical effect
