5Williams W.Principles and practice of pediatric oncology[M].4th edition.Philadelphia:Lippincott,2002:1051-1090.
6Paulussen M,Frohlich B,Jurgens H.Ewing tumour:incidence,prognosis and treatment options[J].Paediatr Drugs,2001,3(12):899-913.
7Graf N,Winkier K,Betlemovic M,et al.Methotrexate pharmacokinetics and prognosis in osteosarcoma[J].Clin Oncol,1994,12(7):1443-1451.
8Bacci G,Ferrari S,Delepine N,et al.Predictive factors of histologic response to primary chemotherapy in osteosarcoma of the extremity:study of 272 patients preoperatively treated with high dose methotrexate,doxorubicin,and cisplatin[J].Clin Oncol,1998,16(2):658-663.
9Bacci G,Loro L,Longhi A,et al.No correlation between methotrexate serum level and histologic response in the pre-operative treatment of extremity osteosarcoma[J].Anticancer Drugs,2006,17(4):411-415.
10Bacci G,Longhi A,Fagioli F,et al.Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities:27 year experience at Rizzol Institute,Italy[J].Eur J Cancer,2005,41(18):2836-2845.