摘要
目的:比较头孢曲松、头孢克肟治疗下呼吸道感染的安全、有效性及医疗经济学意义。方法:选择100名下呼吸道感染病人,随机分为头孢曲松、头孢克肟序贯治疗组(A组)和单用头孢曲松组(B组),每组受试者50例。A组使用头孢曲松1q静脉滴注,每日2次,疗程7d,病情缓解后,转换为头孢克肟胶囊200 mg,每日2次,再治疗7 d。B组单用头孢曲松1g静脉点滴,每日2次,疗程14 d。最后比较二种治疗方法的疗效差异。结果:A组的临床疗效和细菌清除率分别为80％和76％;B组的临床疗效和细菌清除率分别为86％和75％。二组疗效比较无显著性差异(P>0.05)。两组不良反应不常见而轻微。结论:头孢曲松、头孢克肟序贯治疗临床疗效确切可靠、经济、方便。
OBJECTIVE: To evaluate and compare the efficacy, safety and medical economy of ceftriaxone, cefixime sequential therapy and ceftriaxone alone in the treatment of adult patients with lower respiratory tract infection. METHODS: one hundred patients with lower resiratory tract infection were randomly assigned to one of two treatment groups: those received ceftriaxone 1 g iv twice daily for 7 days and then to cefixime 200 mg twice daily for 14 days. Clinical ob-serbation was made once daily and laboratory test including bacte?rology test and chest X -ray film were made before and after study. RESULTS: One hudredpatients (50 with ceftriaxone, cefixime sequential therapy, 50 with ceftriaxone only)were evaluated for clinical efficacy, safety and medical economy. The total duration of treatment for two groups was 14 days. The clinical effective rtate of ceftriaxone, cefixime sequential theraey and control (ceftriaxone only)groups were 80%and 86%, respectively and the bacterial eradication rate was 76% and 75%, respectively and both two drugs are with rare and mild ADRs. CONCLUSIONS: The results obtained indicated that the ceftriaxone, cefixime sequential therapy method is effective, safety and economy in the treatment of patients with lower respiratory tract infection.
出处
《当代医学》
2000年第9期38-39,共2页
Contemporary Medicine
