摘要
目的 探讨生长抑素治疗急性胰腺炎的临床效果。方法 应用人工合成的生长抑素类似物———奥曲肽治疗急性胰腺炎患者 38例 ,结果与 5 9例非奥曲肽治疗组对照。观察了两组以及奥曲肽治疗前后血清淀粉酶及腹腔液淀粉酶的含量 ,比较两组并发症的发生率。结果 奥曲肽治疗组中 ,17例急性水肿性胰腺炎 (AEP)患者、2 1例急性坏死性胰腺炎 (ANP)患者血清淀粉酶及 19例ANP患者腹腔液淀粉酶含量在治疗前分别为 :(932± 6 7)IU/L、(12 47± 43)IU/L、(988± 47)IU/L ;治疗后 48h分别为 (2 74± 5 7)IU/L、(432± 37)IU/L、(176± 32 )IU/L ,治疗前后差异均有显著意义 (P均 <0 0 5 )。奥曲肽治疗组中 2 1例ANP患者发生并发症 18例次 ,非奥曲肽治疗组 2 6例ANP患者发生并发症 38例次。结论 奥曲肽能有效降低血清淀粉酶和腹腔液淀粉酶的活性 ,改善临床症状 ,降低并发症的发生率。
Objective To evaluate the effects of somatostatin in the treatment of patients with acute pancreatitis.[WT5”HZ]Methods [WT5”BZ]We used octreotide —— an analogue of somatostatin to treat 38 cases of acute pancreatitis. Results were compared with that of 59 patients. Serum amylase and that of peritoneal exudate were quantitatively analyzed and the incidence of complications were compared between the two groups.[WT5”HZ]Results [WT5”BZ]In the octreotide group, the average contents of serum amylase in 17 AEP (acute edematous pancreatitis) patients and 21 ANP (acute necrotic pancreatitis) patients and that of peritoneal exudate in 19 ANP patients were (932±67)?IU/L,(1?247±43)?IU/L and (988±47)?IU/L respectively before the treatment of octreotide. The corresponding contents of amyl ase were (274±57)?IU/L, (432±37)?IU/L and (176±32)?IU/L respectively 48?h after the treatment. The differences were all statistically significant ( P <0 05, P <0 05, P <0 05).Eighteen complications developed in 21 ANP patients in octreotide group and of 26 ANP patients in the control group complications developed on 38 occas [CM(43]sions.[WT5”HZ]Conclusion [WT5”BZ] We came to the conclusion that octreotide ameliorates the clinical symptoms and signs, decreases the incidence of complications in patients with ANP.
出处
《中华普通外科杂志》
CSCD
2000年第10期603-605,共3页
Chinese Journal of General Surgery
