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来福美对小鼠药物损伤修复机制的初步探讨

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摘要 目的观察喂服来福美后小鼠对损伤的调节与修复作用,并从氧化损伤角度探讨其可能机制。方法喂服来福美后小鼠用环磷酰胺制作损伤模型,观察不同剂量来福美对模型动物调节与修复指标的影响。结果小鼠化疗模型后体质量均有降低,来福美高、中、低剂量组与对照组相比,差异无统计学意义;各组小鼠外周血各项指标不同程度下降,但灌服不同剂量来福美小鼠,尽管血象下降,血小板值相对下降较对照组小;来福美高、中、低剂量组与对照组比较,脾脏、肝脏中谷胱甘肽(GSH)值皆降低,且降低程度有依次减少的趋势.结论来福美具有明湿增强机体对抗药物损伤后的细胞修复作用。
作者 朱宏 赵维诚
出处 《中国基层医药》 CAS 2013年第22期3450-3451,共2页 Chinese Journal of Primary Medicine and Pharmacy
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