摘要
目的:比较改良法白细胞去除术与传统白细胞去除术在高白细胞白血病治疗中的疗效及不良反应。方法:以84例高白细胞白血病患者为研究对象,其中43例采用改良法白细胞去除术联合化疗(改良组),41例采用传统白细胞去除术联合化疗(传统组)。观察2组白细胞去除前后血细胞的变化、去除术中的不良反应发生率及临床疗效。结果:2种方法都能起到有效清除白血病细胞的作用。改良组去除时间较传统组明显缩短[(127±11)min∶(220±8)min,P<0.05],低血钙和低血容量症状发生率亦明显低于传统组(14.0%∶31.7%,14.0%∶31.7%,均P<0.05)。结论:改良法白细胞去除术清除白血病细胞的效果与传统方法相当,且去除时间缩短,低血钙、低血容量症状等不良反应发生率降低,值得临床推广应用。
Objective：To compare the efficacy and adverse effect between the improved leukapheresis and the traditional leukapheresis on patients with hyperleukocytic leukemia. Method：Eighty-four patients with hyperleuko- cytic leukemia were divided into improved group in which patients accepted the improved leukapheresis followed by chemotherapy （n= 43） and traditional group in which patients accepted the traditional leukapheresis followed by chemotherapy （n=41）. Changes of the blood cell count after leukapheresis,incidence of adverse effect in leukaph eresis and clinical efficacy were evaluated between the two groups. Result：The two methods of leukapheresis could effectively remove leukemic cells. The operating time in improved group was shorter than that in traditional group [（127±11） min vs （220±8） min,P〈0.05]. The incidence of hypocalcemia and hypovolaemic symptoms in im- proved group were lower than those in traditional group （14.0% vs 31.7% ,14.0% vs al. 7% ,P〈O. 05）. Conclu- sion：The improved leukapheresis can remove leukemic cells effectively as the traditional method, and reduce the op crating time and incidence of hypocalcemia and hypovolaemic symptoms. The improved leukapheresis is worthy of clinical application.
出处
《临床血液学杂志》
CAS
2013年第5期635-636,641,共3页
Journal of Clinical Hematology
