摘要
目的：探讨心脏死亡器官捐献（DCD）供者肾移植的临床效果. 方法：回顾性分析发生急性肾衰竭（ARF）的DCD供者肾移植临床资料. 结果：来自15例ARF供者的30个肾脏植入29例受者体内（其中1例接受双肾移植）.供体起始和终末血清肌酐分别为90.1±35.1 μmol/L和355.6±153.1 μmol/L.术后8例（27.6％）受者发生移植肾功能延迟恢复,随访2 ～21月,人肾存活率均为100％.术后1月和12月肾小球滤过率分别为55.5±10.5 ml/（min·1.73m2）和60.8±10.6 ml/（min·1.73m2）. 结论：DCD供者肾移植术后的近期效果良好,是扩大供肾来源的潜在途径.
Objective：To explore the clinical effect of kidney transplantation from DCD donors with acute renal failure （ARF）.Methodology：Kidney transplantation from DCD donors with ARF from August 2011 to March 2013 was retrospectively reviewed.All donors were China type Ⅲ donors （donation after cardiac death of brain death patients）.ARF was defined by RIFLE criteria.Results：Thirty kidneys from 15 donors with ARF were transplanted into 29 recipients with one patient received dual kidney transplants.Initial and terminal SCr of these donors were （90.1 ± 35.1） μmol/L and （355.6-153.1） μmoL/L respectively.Delayed graft function （DGF） occurred in 8 （27.6％） recipients and all recovered within 4 weeks.With a follow-up of 1 ～ 21 months,both patient and kidney graft survival were 100％.Mean one and 12-month glomerular filtration rate were （55.5 ± 10.5） ml/（min· 1.73m2） and （60.8 ± 10.6） ml/（min· 1.73m2）respectively.Conclusion：Kidneys from DCD donors with ARF have excellent short-term outcomes and may represent another potential method to safely expand the donor pool.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2013年第4期336-339,共4页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
卫生部部属(管)医院临床学科重点项目(2010159)
广东省科技计划重点项目(2011A030400005)
关键词
肾移植
心脏死亡器官捐献
急性肾衰竭
kidney transplantation
donation after cardiac death
acute renal failure
