摘要
免疫抑制剂的毒副作用常常是影响肝移植受者长期生存的危险因素。免疫抑制个体化治疗是目前肝脏移植综合治疗的热点和难点。免疫抑制治疗已从仅着眼于移植术后抗免疫排斥反应，逐步向追求患者和移植物长期存活、药物副作用最小化、优化患者生命质量，同时降低患者经济负担方向发展。通过掌握各类免疫抑制剂特点及毒副作用，正确有效地评估受者的免疫状态，结合患者自身病理生理状况，有针对性地选择免疫抑制治疗方案，达到药物剂量最小化，实现个体化给药方案。
The toxic effects of immunosuppressants are often dangerous factors which influence long-term survival of recipients. Individualized immunosuppressive therapy has been a hotspot and difficulty for comprehensive treatment of liver trans- plantation. Immunosuppressive therapy has been gradually developed to pursue long-term survival for receipients and graft, minimized side effects of immunosuppressants, optimized quality of life of patients, and reduce the economic burden of patients. Through consideration of patient＇s pathophysiological state, understanding the characteristics and side effects of various immunosuppressive, appropriate choose of the immune inhibitor, correct evaluation of immune state of recipients and graft, mini- mization of drug doses, individualized dosing regimen could be successfully carried out.
出处
《中华消化外科杂志》
CAS
CSCD
北大核心
2013年第9期652-654,共3页
Chinese Journal of Digestive Surgery
基金
国家自然科学基金（81070376）
关键词
肝移植
免疫抑制剂
个体化治疗
Liver transplantation
Immunosuppres-sant
Individualized therapy
