摘要
目的：观察心理干预在非小细胞肺癌患者首次化疗中的应用效果.方法：随机抽取2009年5月至2013年5月期间我院收治的非小细胞肺癌确诊患者94例,PS评分均为0分～1分,1：1随机分为干预组与对照组,所有患者化疗方案均为吉西他滨＋顺铂,干预组患者增加心理干预,分别在治疗前和治疗后对患者进行SAS以及SDS评分,并在治疗后对患者生活质量进行评分.结果：治疗前两组患者的平均SAS及SDS评分差异无统计学（P＞0.05）,干预组患者治疗后的平均SAS评分为（22.19 ＋7.84）,明显低于治疗前（42.06±10.74）,差异有统计学意义（t=22.511,P＜0.05）,对照组的平均SAS评分为（41.76±9.58）,与治疗前（45.59±14.62）相比差异无统计学,两组比较干预组的平均SAS评分明显低于对照组（t=11.946,P＜0.05）；干预组治疗后的平均SDS评分为（25.49±6.12）,明显低于治疗前（46.15±13.84）,差异有统计学意义（t=26.490,P＜0.05）；对照组的平均SDS评分为（43.72±14.67）,与治疗前相比无统计学差异,组间比较干预组的平均SDS评分明显低于对照组（t＝20.818,P＜0.05）.干预组患者首次化疗结束后进行生活质量评分得分为4-5分的明显高于对照组（x2=29.716,P＜0.05）,差异具有统计学意义.结论：在非小细胞肺癌患者首次进行化疗的过程中进行心理干预可有效提高其治疗后的生活质量,值得临床推广.
Objective： To observe the effect of psychological intervention applied in the first course of chemotherapy for pa- tients with non-small cell lung cancer. Methods ： Ninety-four cases of non-small lung cancer treated in our hospital with PS score of 0 - 1 from May 2009 to May 2013 were included in our study. Forty-seven cases were selected in intervention group, and 47 cases in control group. All of them were given the chemotherapy regimen of Gemcitabine plus Cisplatin, and psychological intervention was add- ed in intervention group. Modified SAS and SDS scores were evaluated before and after treatment, and quality of life was graded after treatment. Results： There was no statistically significant difference of mean modified SAS and SDS scores between the two groups he- fore treatment（ P 〉 0.05 ）. After treatment, mean modified SAS score in intervention group was （22. 19 ＋-7.84）, which was much low- er than that before treatment （42. 06 ~ 10. 74,t =22. 511, P 〈0. 05）, and mean modified SAS score in control group was（41.76 _＋ 9. 58 ） , which had no statistically significant difference with that before treatment（45.59 -＋ 14. 62 ） , and mean modified SAS score in intervention group was lower than that in control group （ t = 11. 946, P 〈 0. 05 ）. Mean modified SDS score in intervention group was （25.49 ＋6. 12）, which was much lower than that before treatment （t =26. 490, P 〈0. 05）, and mean modified SDS score in control group was（43.72 -＋ 14. 67 ）, which had no statistically significant difference with that before treatment, and mean modified SDS score in intervention group was lower than that in control group （ t =20. 818, P 〈0. 05）. The cases with score of quality of life from 4 to 5 were more in intervention group than that that in control group （X2 = 29. 716, P 〈 0. 05 ）. Conclusion： Quality of life of patients with non-small cell lung cancer after treatment could be effectively improved by psychological intervention added in at the first course of chemotherapy. It is worthy of clinical application.
出处
《肿瘤预防与治疗》
2013年第4期226-228,250,共4页
Journal of Cancer Control And Treatment
关键词
非小细胞肺癌
吉西他滨
顺铂
心理干预
生活质量
Non-small Cell Lung Cancer
Gemcitabine
Cisplatin
Psychological Intervention
Quality of Life
