摘要
目的探讨大剂量尿激酶超早期静脉溶栓治疗急性脑梗塞的临床疗效及安全性。方法对 2 2例发病12h内的急性脑梗塞患者一次性应用 2 0 0万U尿激酶静脉溶栓治疗 ,观察溶栓后 2h、12h、1d、3d、7d、14d、2 8d时神经功能缺损积分减少程度、治愈率、显效率、总有效率 ,并与常规治疗进行比较。结果溶栓后 1d神经功能缺损积分 17.5 5± 12 .74,较溶栓前 2 9.0 0± 7.77明显减少 ,两者比较差异有显著意义 (P <0 .0 0 1) ,治愈率、显效率分别达到 13.6 %和 45 .5 % ;溶栓后 2 8d神经功能缺损积分减少程度、治愈率、显效率、总有效率均明显高于对照组。溶栓组有 3例并发脑出血 ,4例牙龈出血 ;对照组有 1例并发脑出血。结论尿激酶超早期静脉溶栓治疗急性脑梗塞临床疗效好。
ObjectiveTo determine the clinical curative effect and safety of ultra early intravenous thrombolysis with high-dose urokinase in treatment of acute cerebral infarction.Methods22 patients with acute cerebral infarction were treated with a single dose of 200×10 4 urokinase as intravenous thrombolytic therapy within 12 h after the onset . The decrease degree of nerve function defect integral, the cure rate, the effectual rate, and the total effective rate were observed 2 h, 12 h, 1 d, 3 d, 7 d, 14 d and 28d after thrombolysis respectively, and the results were compared with those of conventional treatment. ResultsThe nerve function defection integral examined 1d after thrombolysis ( 17.55 ± 12.74 ) was markedly lower than that before thrombolysis ( 29.00 ± 7.77 ). A remarkable difference (P< 0.001 ) was noticed between them. The cure and effectual rate reached 13.6 % and 45.5 % , respectively. The decrease degree of nerve function defect integral, the cure rate, the effectual rate and the total effective rate evaluated 28 days after thrombolysis were all higher than those of conventional therapy group. Among the 22 cases in thrombolyysis group,3 cases were complicated with cerebral haemorrhage and 4 with gum bleeding.While in control group,one case of carebral haemorrhage was found.ConclusionUltra early intravenous thrombolysis with urokinase in the treatment of acute cerebral infarction has a better clinical curative effect.
出处
《河北医科大学学报》
CAS
2000年第6期327-330,共4页
Journal of Hebei Medical University
关键词
急性脑梗塞
溶栓疗法
尿激酶
临床研究
治疗
cerebral infarction/therapy
urokinase/therapeutic use
clinical studies
