摘要
目的探讨重型肝炎合并真菌感染的易感因素及预防治疗措施,以提高抢救成功率。方法回顾性分析2008年9月-2011年12月医院收治的重型肝炎合并真菌感染的病例为研究组,并取同期住院的无真菌感染的重型肝炎患者作为对照组,对相关资料进行统计分析。结果重型肝炎合并真菌感染白色假丝本酵母菌最为常见占50.0%;感染部位以呼吸道及肠道为主,分别占80.8%、23.1%;应用广谱抗菌药物、激素、侵入性诊疗措施、病情严重程度与真菌感染发生密切相关(P<0.05);重型感染合并真菌感染患者病死率高,为61.5%。结论重型肝炎合并真菌感染危险因素较多,临床病死率较高,针对相关因素进行预防和治疗,可提高重型肝炎抢救成功率。
OBJECTIVE To explore the risk factors and preventive measures of severe hepatitis complicated with fungal infections so as to raise the success rate of rescue. METHODS The patients with severe hepatitis complicat- ed with fungal infections, who were treated in the hospital from Sep 2008 to Dec 2010 were retrospectively analyzed, and the severe hepatitis patients without fungal infections were set as the control group; the statistical analysis of related data was performed. RESULTS Candida albicans was the most common species causing fugal infections in the patients with severe hepatitis, accounting for 50.0%; the respiratory tract and the intestinal tract were the predominant infection sites, accounting for 80.8% and 23. 1%, respectively. The use of broad-spectrum antibiotics and corticosteroids, invasive diagnosis and treatment, and severity of illness were closely related to the incidence of the fungal infections~ the mortality of the severe hepatitis patients complicated with fungal infections was high （61.5%）. CONCLUSION There are many factors associated with the fungal infections in the patients with severe hepatitis, the clinical mortality is high. It can raise the success rate of the rescue of the patients with severe hepatitis in a way to focus on the prevention and treatment on the basis of the related factors.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第15期3813-3814,3817,共3页
Chinese Journal of Nosocomiology
关键词
重型肝炎
真菌感染
治疗转归
Severe hepatitis
Fungal infection
Treatment outcome
