摘要
目的:探讨脑复康联合多奈哌齐治疗脑卒中后认知功能障碍的改善情况。方法:将80例脑卒中后认知功能障碍患者采用随机对照的方法分为两组,对照组患者给予积极治疗原发病、脱水、改善脑供血、康复训练等常规治疗方法;治疗组在常规治疗方法的基础上同时给予脑复康联合多奈哌齐治疗,两组患者观察治疗4周。在治疗前后对患者采用简易精神状态量表(MMSE)进行评分。结果:两组患者在治疗前MMSE评分差异无统计学意义(P>0.05);对照组治疗后MMSE评分较治疗前有改善,但治疗前后的差异无统计学意义(P>0.05);治疗组治疗后MMSE评分较治疗前有着明显改善,在定向力、记忆力、语言表达能力及总分方面差异有统计学意义(P<0.05)。结论:脑复康联合多奈哌齐可以有效改善脑卒中后认知功能障碍,提高患者的生活质量。
Objective To observe the effect of piracetam combined with donepezil on cognitive function in patients with post - stroke. Method 80 cases of post - stroke patients with cognitive dysfunction were randomly divided into two groups, the control group was given conventional treatment of the primary disease, dehydration, improving the blood supply to the brain, rehabilitation training and psycho- logical support;the treatment group at the same time was given a combination of piracetam 4g joint 250ml saline, intravenous infusion and donepezil tablets with 5rag,1 times one day,on the basis of conventional treatment. Each group of patients treated and followed - up for 4 weeks. The Mini -Mental State Examination （MMSE） was used at Pre - treatment and treatment at the end of 4 weeks. Results MMSE Scale score showed no statistical difference between two groups of patients before treatment （ P 〉 0.05 ） ; 4 weeks after treatment, MMSE Scale score of the control group showed improvement,but no statistical difference was observed when compared with Pre -treatment （P 〉 0. 05 ） and MoCA Scale score of the treatment group show significantly improvement ,with statistical difference on the faculty of disorienta- tion, memory and language skills （ P 〈 0. 05 ）. Conclusion The efficacy of piraeetam combined with donepezil on cognitive function improve- ment in patients of post - stroke is confirmed.
出处
《吉林医学》
CAS
2013年第25期5118-5120,共3页
Jilin Medical Journal
