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IL-17水平检测对妊娠期自身免疫性甲状腺病的预警价值 被引量：2

The value of IL-17 detection in the prewarning of autoimmune thyroid disease for pregnant women
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摘要 目的研究血浆IL-17水平检测对孕妇患自身免疫性甲状腺病的预警价值。方法采用ELISA检测132例孕妇(分为正常妊娠组和AITD妊娠组),33例患AITD的育龄妇女(未怀孕)和40例健康体检育龄妇女血浆IL-17水平。结果 AITD妊娠孕妇血浆IL-17水平明显高于正常妊娠的孕妇(P<0.05)。结论孕妇血浆IL-17水平的检测有助于预警自身免疫性甲状腺疾病的发生。 Objective To study the value of IL-17 level measurement in the prewarning of autoimmune thyroid disease（AITD） for pregnant women. Methods 132 eases of pregnant women were recruited in the study,which were divided into normal pregnant group and AITD pregnant group. In addition to that, 33 women of child-bearing age and 40 healthy women were also recruited. ELISA was adopted to detect the level of plasma IL-17 for the people mentioned above. Results The plasma IL-17 levels in preg- nancy women with AITD were significantly higher than normal pregnant women（P〈0.05）. Conclusion The measurement of ma- ternal plasma levels of IL-17 helps early warning for autoimmune thyroid disease.
作者 苑林
机构地区 广东省中医院芳村分院检验科
出处 《国际检验医学杂志》 CAS 2013年第15期1961-1962,共2页 International Journal of Laboratory Medicine
关键词 白细胞介素17 甲状腺炎 自身免疫性 孕妇 interleukin-4 thyroiditis autoimmune pregnant women
分类号 R714.25 [医药卫生—妇产科学]
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参考文献10

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同被引文献23

  • 1Sgarbi JA,Maciel RM. Pathogensis of autoimmune thyroid diseases [ J]. Arq Bras Endocrinol Matabo1,2009,53 ( 1 ) :5 - 14.
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  • 4Ozbek MN, Uslu AB, Oneoli-Mungan N, et al. Thyroid peroxidase gene mutations causing cottgenital hypothyroidism in three Turkish families[ J]. Pediatr Endocrinol Metab ,2009,22 ( 11 ) : 1033 - 1039.
  • 5Xie LD, Gao Y, Li MR, et al. Distribution of immunoglobulin G sub- classes of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status [ J ]. Clin Exp Immuno1,2008,154 ( 2 ) : 172 - 176.
  • 6Figueroavega N,Alfonsop6rez M,Benedicto I, et al. Increased circu- lating pro-inflammatory cytokines and Thl7 lymphocytes in hashimo- to' s thyroiditis [ J ]. J Clin Endocrinol Metab,2010,95 ( 2 ) : 953 - 962.
  • 7Hsu HC ,Yang P,Wang J,et al. Interleukin 17 - producing T helper ceils and interleukin 17 orchestrate autoreactive germinal center de- velopment in autoimraune BXD2 mice [ J ]. Nat Immunol, 2008,9 (2) :166 - 175.
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  • 9马尔江,胡那西别克.血清TGAb、TMAh、TPOAb对诊断自身免疫性甲状腺病的评价[D].乌鲁木齐:新疆医科大学,2011.
  • 10赵永胜,赵丛雯,申群喜,曾云,黄铁军,邱洁,高素清.妊娠妇女自身免疫性甲状腺疾病筛查、监测和干预研究[J].中国热带医学,2008,8(8):1312-1314. 被引量：4

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国际检验医学杂志
2013年 第15期

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