期刊文献+

术后血浆褪黑素水平与老年患者术后谵妄发生的相关性 被引量:7

原文传递
导出
摘要 目的探讨血浆褪黑素浓度与老年患者术后谵妄发生的相关性。方法138例行择期手术的老年患者于术后当晚和术后第1天上午分别行ICU精神错乱评估法评分判断是否发生谵妄,当发生谵妄的患者达到20例时将所有发生谵妄的患者作为谵妄组(D组),并同时随机选取20例未发生谵妄的患者作为对照组(c组)。所有老年患者均于手术当日早晨6点、术后第1天早晨6点分别留取血浆样品,采用放射免疫法检测血浆褪黑素浓度。结果两组术前血浆褪黑素浓度差异无统计学意义(P〉0.05),但D组术后血浆褪黑素浓度低于c组(P〈0.01),两组老年患者的术后血浆褪黑素浓度与术前相比均显著下降(P〈0.01),D组术前术后血浆褪黑素差明显大于C组(P〈0.01)。结论术后血浆褪黑素浓度及术前与术后血浆褪黑素浓度差与患者术后谵妄的发生有关。
出处 《中国医师杂志》 CAS 2013年第7期958-960,共3页 Journal of Chinese Physician
  • 相关文献

参考文献10

  • 1Witlox J,Eurelings LS,de Jonghe JF,et al.Delirium in elderly patients and the risk of postdischarge mortality,institutionalization,anddementia:a meta-analysis.JAMA,2010,304 (4):443-451.doi:10.1001/jama.2010.1013.
  • 2Mantz J,Hemmings HC Jr,Boddaert J.Case scenario:postoperative delirium in elderly surgical patients.Anesthesiology,2010,112(1):189-195.doi:10.1097/ALN.0b013e3181c2d661.
  • 3Bourne RS,Mills GH.Melatonin:possible implications for the postoperative and critically ill patient.Intensive Care Med,2006,32(3):371-379.
  • 4Markus CR,Olivier B,Panhuysen GE,et al.The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other largeneutral amino acids,and in vulnerable subjects raises brain serotonin activity,reduces cortisolconcentration,and improves mood under stress.Am J Clin Nutr,2000,71 (6):1536-1544.
  • 5Esposito E,Cuzzocrea S.Antiinflammatory activity of melatonin in central nervous system.Curr Neuropharmacol,2010,8 (3):228-242.doi:10.2174/157015910792246155.
  • 6de Jonghe A,van Munster BC,van Oosten HE,et al.The effects of melatonin versus placebo on delirium in hip fracture patients:study protocol of arandomised,placebo-controlled,double blind trial.BMC Geriatr,2011,11:34.doi:10.1186/1471-2318-11-34.
  • 7Gunther ML,Morandi A,Ely EW.Pathophysiology of delirium in the intensive care unit.Crit Care Clin,2008,24(1):45-65,viii.doi:10.1016/j.ccc.2007.10.002.
  • 8Hanania M,Kitain E.Melatonin for treatment and prevention of postoperative delirium.Anesth Analg,2002,94(2):338-339.
  • 9K(a)rkel(a) J,Vakkuri O,Kaukinen S,et al.The influence of anaesthesia and surgery on the circadian rhythm of melatonin.Acta Anaesthesiol Scand,2002,46 (1):30-36.
  • 10Sultan SS.Assessment of role of perioperative melatonin in prevention and treatment of postoperativedelirium after hip arthroplasty under spinal anesthesia in the elderly.Saudi J Anaesth,2010,4 (3):169-173.doi:10.4103/1658-354X.71132.

同被引文献76

引证文献7

二级引证文献47

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部