摘要
目的 为评价国产降纤酶对急性脑梗死的治疗效果及安全性。 方法 以低分子右旋糖酐、钙离子拮抗剂、银杏制剂为对照药 ,从 1 998年 1月至 1 999年 1月共观察脑梗死急性期脑梗死 (发病 7天内 )病人 30例 ,对照组 1 4例。 结果 用降纤酶治疗脑梗死第 1天 ,临床症状即出现明显改善 ,其疗效在治疗后第 1天、第 7天、第 1 4天均明显优于对照组。 结论 认为降纤酶治疗急性脑梗死疗效是肯定的。从实验室检查发现 ,降纤酶可明显降低纤维蛋白原 ,并使凝血酶原时间延长 ,这与以往研究结果完全一致 ,表明降纤酶是通过降低纤维蛋白原而改善临床症状的。本组研究资料提示 ,降纤酶可降低血浆中纤维蛋白原 ,对急性脑梗死有明显疗效 ,未发现有明显副作用。因此 ,我们认为在有凝血指标监护下使用降纤酶治疗急性脑梗死是安全有效的 ,值得在临床上进一步推广。
Objective We decided to study the effect and safty of China-made defibrase in treating acute cerebral infarction Method Neurological defect was evaluated according to the draft of neurological defect evaluation in Yangzhou in 1986 ,The plasmic fibrinogen (FIB),prothrombin time (PT) were detected before and after therapy The treatment group (n=30) was treated with defibrase ,the control group(n=14) was treated with calcium antagonist,etc Results The clinical symptoms were improved significantly in the treatment group one day after therapy The clinical effects of the treatmant group were better than the control group in seven and fourteen days respectively Defibrase could decrease FIB concentration and prolong PT Defibrase could cause no obvious side-effects Conclusions It was effective and safe to treat acute cerebral infarction with defibrase
出处
《蛇志》
1999年第4期37-39,共3页
Journal of Snake
关键词
脑梗死
降纤酶
纤维蛋白原
凝血酶原时间
cerebral infarction,defibrase,fibrinogen plasma,prothrombin time
