摘要
越来越多的黄酮类化合物被发现具有潜在治疗阿尔茨海默病(AD)的功效。研究证明,具有活性的低分子量黄酮类物质或其代谢产物通过降低氧化应激、神经炎症,增加脑血流量和引发海马神经形成发挥神经保护作用。部分黄酮类化合物能够抑制β分泌酶(BACE-1),激活α-分泌酶(ADAM10),抑制tau蛋白过度磷酸化或乙酰胆碱酶活性发挥治疗AD作用。该文将讨论黄酮类化合物发挥AD防御作用的可能机制。
An increasing number of studies have indicated that flavonoids have potential therapeutic effect in Alzbeimer disease（AD）. It is now believed that the activity of these low-molecular-weight and their metabolites on neurological processes can be defined through a number of distinct biological processes. For example ,recent evidence indicates that flavonoids protects the brain against various oxidative stressors, reduces neuroinflammation,increases brain bloodflow and initiate neurogenesis in the hippoeampus. Additional mechanisms have been suggested for the ability of flavonoids to treat AD through the inhibition of 13-secretase （ BACE-1 ） and/or activation of a-secretasc（ADAM10） ,inhibition of tau hyperphosphorylation or acetylcho- linesterase. Here is to make a review of the probable pathophysiological mechanisms of the defending role of flavonoids in AD.
出处
《医学综述》
2013年第17期3086-3089,共4页
Medical Recapitulate
基金
广西实验动物资源共享服务平台建设(11-31-10)
