5Osborne NN, Casson RJ, Wood JP, et al. Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res,2004 ,23 :91-147.
6Rogawski MA, Loscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci ,2004,5:553-564.
7Phiel C J, Zhang F, Huang EY, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem,2001,276 :36734-36741.
8Gottlicher M, Minucci S, Zhu P, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed ceils. EMBO J,2001,20 :6969-6978.
9Kim HJ, Rowe M, Ren M, et al. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther,2007,321:892-901.
10Hassel B, Iversen EG, Gjerstad L, et al. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. J Neurochem, 2001,77 : 1285-1292.
2Becquet F, Courtois Y, Goureau O. Nitric oxide in the eye. multifaeeted roles and diverse outcomesJ. Surv Ophthal- mo1,1997,42(1) :71-82.
3Liu RH, Hotchkiss JH. Potential genotoxicity of chronically elevated nitric oxide.-a review[J]. Mutat Res, 1995, 339(2) :73-89.
4Takeda M, Mori F, Yoshida A, et al. Constitutive nitric oxide synthase is associated with retinal vascular permea- bility in early diabetic rats[J]. Diabetologia, 2001,44 (8) : 1043-1050.
5Sennlaub F,Courtois Y,Goureau O. Inducible nitric oxide synthase mediates retinal apoptosis in ischemic prolifera- tive retinopathy[J]. J Neurosci,2002,22(10) :3987-3993.
6Marsden PA, Heng HH, Duff CL, et al. Localization of the human gene for inducible nitric oxide synthase (NOS2) to chromosome 17qll. 2-q12 [J]. Genomics, 1994,19 (1) . 183-185.
7Kr6ncke KD, Fehsel K, Kolb-Bachofen V. Nitric oxide: cytotoxicity versus cytoprotection-how, why, when, and where[J]. Nitric Oxide. 1997,1(2) : 107-120.