摘要
目的 探讨血肾素活性 (PRA)和血管紧张素Ⅱ (PANGⅡ )在多囊卵巢综合征 (PCOS)发病中的作用。方法 采用放射免疫法对 30例PCOS患者 (PCOS组 )和 30例月经周期正常的妇女 (对照组 )进行PRA和PANGⅡ水平测定。结果 PCOS组PRA、PANGⅡ水平为 (6 .99± 3.17) μg·L-1·h-1与(90 .2± 36 .2 )ng/L ,均明显高于对照组卵泡期水平 [(1.84± 1.12 ) μg·L-1·h-1,(4 2 .3± 13.0 )ng/L],其中高睾酮 (T)者PRA、PANGⅡ与黄体生成素 (LH) /促卵泡激素 (FSH)、T呈正相关关系。结论 PCOS患者有肾素 血管紧张素系统亢进现象 。
Objective To investigate changes of plasma renin activity(PRA)and plasma angiotensinⅡ(PANGⅡ)in women with polycystic ovary syndrome(PCOS). Methods We chose thirty PCOS women as trial group and thirty normal menstrual women as control.PRA and PANGⅡ levels during follicularphase(FP) of the two groups were measured by radioimmunoassay. Results PRA and PANGⅡ increased in women with PCOS as compared with the normal FP. The increment of PRA and PANGⅡ in PCOS women of high testosterone levels was correlated with serum luteinizing hormone/follicle stimulating hormone and testosterone concentration. Conclusion The elevated PRA and PANGⅡsuggest an enhanced functional activity of ovarian renin angiotensin system in PCOS,and which may play a role in the pathologenesis of PCOS.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2000年第10期586-587,共2页
Chinese Journal of Obstetrics and Gynecology
