摘要
目的 :探讨肾移植患者血中内皮素 (ET)和一氧化氮 (NO)的临床意义。方法 :对 32例肾移植患者进行外周血 ET- 1和 NO动态检测 ,将检测结果与对照组进行比较 ,并按移植肾状况和血压值再分别分组进行比较。结果 :肾移植后 ET- 1值较对照组明显下降 (P <0 .0 5) ,NO值明显升高 (P <0 .0 1 ) ;急性排斥反应发生时 ,NO值较正常和慢性排斥反应者升高 (P <0 .0 1 ) ,而发生慢性排斥反应时 ,ET- 1值较肾功能正常时明显升高 (P <0 .0 1 )。高血压组的 ET- 1值较高而 NO水平较低。结论 :检测血中的 ET- 1和 NO值有助于肾移植后排斥反应的诊断 ,且有利于指导护肾治疗。
Purpose:To investigate the clinical significance of endothelin(ET) and nitric oxide(NO) analysis in renal allograft recipients.Methods:Blood ET-1 and NO were measured in 32 cases of renal allograft recipients.Results:The ET-1 levels reduced(P< 0.05 ) and NO levels rose(P< 0.01 ) after renal transplantation. In patients with acute rejection, the NO level was markedly higher than that in normal group and in chronic rejection group(P< 0.01 ).In patients with chronic rejection, the ET-1 level was higher than that in normal group(P< 0.01 ). While the NO level was lower than that in patients with hypertension.Conclusions:The analysis of blood ET-1 and NO would be used to diagnose renal allograft rejection, and contribute to the anti-damage treatment of graft after renal transplantation.
出处
《临床泌尿外科杂志》
2000年第10期441-442,共2页
Journal of Clinical Urology
关键词
肾移植
内皮素
一氧化氮
排斥反应
Kidney transplantation Endothelin Nitric oxide Rejection
