摘要
目的探讨消化性溃疡并发出血的危险因素,并根据危险因素进行干预,以降低溃疡并发出血的发生。方法随机选取2010年12月至2013年1月由宝鸡市中心医院消化内科收治的84例消化性溃疡并发出血的患者作为病例组,另选取同期收治的84例消化性溃疡非出血患者作为对照组,然后进行危险因素分析。结果吸烟史、酗酒史、服用非甾体消炎药、伴随症状、溃疡数目、溃疡处于活动期、凝血功能异常、幽门螺杆菌是消化性溃疡并发出血的危险因素,其中的吸烟酗酒史、伴随症状、溃疡处于活动期、幽门螺杆菌阳性是高危险因素。在两组病例中,病例组吸烟史、酗酒史、服用非甾体消炎药、伴随症状、溃疡数目、溃疡处于活动期、凝血功能异常、幽门螺杆菌的发生率分别为33.3%、38.1%、33.3%、36.9%、39.3%、28.6%、36.9%、40.5%;而对照组相对于的发生率分别为11.9%、25%、7.1%、14.3%、16.7%、8.3%、13.1%、13.1%,两组比较差异有统计学意义(P<0.05)。采用Logistic多因素危险因素分析,吸烟酗酒史、伴随症状、溃疡处于活动期、幽门螺杆菌阳性的P值分别为0.029、0.013、0.021、0.036。结论吸烟酗酒史、伴随症状、溃疡处于活动期、幽门螺杆菌阳性是消化性溃疡并发出血的独立危险因素,在临床上要加以干预。
Objective To investigate the risk factors for peptic ulcer bleeding,and make interventions according to risk factorsin order to reduce ulcer complicated hemorrhage.Methods Randomly selected from December 2010 to January 2013 admitted by the Department of Gastroenterology,Baoji Central Hospital 84 cases of patients with peptic ulcer bleeding were the case group,and the other 84 cases of non-bleeding peptic ulcer treated during the same period were were control group,and then the risk factors were analyzed.Results Smoking history,history of alcohol abuse,taking non-steroidal anti-inflammatory drugs NSAIDs,concomitant symptoms,number of ulcers,ulcers in the active stage,coagulation dysfunction,and Helicobacter pylori were risk factors for peptic ulcer complicated bleeding,among which smoking history,alcohol abuse,accompanying symptoms,ulcers in the active stage,H.pylori were high risk factors.In the case group percentage of smoking history,history of alcohol abuse,taking non-steroidal anti-inflammatory drugs,along symptoms,number of ulcers,ulcers in the active stage,coagulation abnormalities,and H.pylori were 33.3%,38.1%,33.3%,36.9%,39.3%,28.6%,36.9%,40.5%;while in the control group the corresponding data were 11.9%,25%,7.1%,14.3%,16.7%,8.3%,13.1%,13.1% respectively,and there were significant differences between the two groups（P 0.05）.Logostic multivariate analysis P values for risk factors of history of smoking and alcohol abuse,associated symptoms,ulcers in the active stage,H.pylori were 0.029,0.013,0.021,0.036.Conclusion Smoking and alcohol abuse history,associated symptoms,ulcers in the active stage,H.pylori-positive are independent risk factors for peptic ulcer bleeding,which should be intervened in clinical.
出处
《医学综述》
2013年第16期3054-3056,共3页
Medical Recapitulate
关键词
消化性溃疡
出血
危险因素
干预对策
Peptic ulcer
Bleeding
Risk factors
Intervention countermeasures
