摘要
目的探讨帕瑞昔布钠联合曲马多对食管癌根治术后镇痛效果的影响。方法选取2010年9月至2013年1月在青海交通医院就诊的择期行中下段食管癌根治术的患者80例,按随机数字表法分为两组,A组(40例)关腹及术后12 h静脉注射帕瑞昔布钠40 mg+曲马多1 mg/kg镇痛;B组(40例)单纯使用吗啡镇痛。于手术后2 h(T1)、4 h(T2)、12 h(T3)、24 h(T4)、48 h(T5)记录两组患者疼痛VAS及镇静程度Ramsay评分,比较两组患者麻醉后恢复室(PACU)内需镇痛人数及术后首次要求镇痛时间,并观察不良反应。结果两组患者VAS及Ramsay评分组间比较、不同时间点比较、组间.不同时间点比较,差异均有统计学意义(P<0.05);A组PACU内需镇痛人数与B组相比,差异无统计学意义(P>0.05);首次要求镇痛时间与B组相比,差异有统计学意义(P<0.01);两组不良反应发生情况比较,差异有统计学意义(χ2=4.013,P<0.05)。结论帕瑞昔布钠联合曲马多可有效缓解食管癌根治术后疼痛,不良反应小,值得推广应用。
Objective To investigate the analgesia effect of parecoxib sodium combined with tramadol for postoperative esophageal cancer radical mastectomy.Methods Eighty patients from Qinghai Traffic Hospital during Sep.2010 to Jan.2013 were randomly divided into two groups,group A（n = 40） was given parecoxib sodium 40 mg ＋ tramadol 1 mg / kg intravenously at abdomen closure and postoperative 12 h,while group B（n =40） was given morphine analgesia only.Visual analogue scale（VAS）,Ramsay sedation score,the number of PACU domestic demand for analgesia and the postoperative analgesia time for the first time were recorded at 2 h（T1）,4 h（T2）,12 h（T3）,24 h（T4）,48 h（T5） after surgery,observing the adverse reactions.Results Comparing the two groups,at different time points and the different time points between two groups,there were no statistically significant difference in VAS score and Ramsay score（P 0.05）.The PACU domestic demand number of analgesia of group A and B had no statistically significant difference（P 0.05）.First request analgesia time of the two groups had statistically significant difference（P 0.01）.There were no significant difference in adverse reactions between the two groups（χ2 = 4.013,P 0.05）.Conclusion Analgesia effect of parecoxib sodium combined with tramadol for postoperative esophageal cancer radical mastectomy is significant,and adverse reactions are little,thus is worth for popularizing.
出处
《医学综述》
2013年第16期3052-3054,共3页
Medical Recapitulate
关键词
帕瑞昔布钠
曲马多
吗啡
食管癌根治术
镇痛
Parecoxib sodium
Tramadol
Morphine
Esophageal cancer radical mastectomy
Analgesia
