摘要
目前,冠状动脉粥样硬化性心脏病(冠心病)发病率逐年增高,严重影响患者的生活质量。尼可地尔是一种具有硝酸酯类作用的钾离子通道开放剂,可以显著地改善稳定性以及不稳定性心绞痛患者症状,改善生活质量。同时亦可以降低冠心病患者全因病死率,改善长期预后。另外,冠心病的介入治疗广泛开展,介入治疗的并发症包括经皮冠状动脉介入治疗相关的心肌损伤以及心肌梗死亦逐渐增多。尼可地尔可以显著减少围术期心绞痛的发作,预防围术期冠状动脉慢血流,达到保护心肌的作用。
At present,the incidence of coronary heart disease is increasing year by year,seriously affecting the quality of life of the patients.Nicorandil is a potassium channel opener with nitrate effect,which can significantly improve symptoms and the quality of life in patients with stable angina pectoris and unstable angina.At the same time it can also reduce all-cause mortality in patients with coronary heart disease,and improve the long-term prognosis.In addition,along with the wide application of percutaneous coronary intervention（PCI）,complications including myocardial injury and myocardial infarction associated with PCI are gradually increasing.Nicorandil can reduce angina pectoris attack during operation period,prevent coronary slow reflow,and achieve the effect of myocardial protection.
出处
《医学综述》
2013年第16期2930-2932,共3页
Medical Recapitulate
关键词
尼可地尔
心绞痛
经皮冠状动脉介入治疗
心肌保护
应用进展
Nicorandil
Angina pectoris
Percutaneous transluminal coronary intervention
Myocardial protection
Application progress
