摘要
目的探讨保留乳头乳晕复合体(nipple-areolar complex,NAC)的乳腺癌改良根治术对早期乳腺癌的临床疗效。方法选取40例行保留NAC改良根治术和40例行传统改良根治术的早期乳腺癌患者,按1∶1比例进行配对回顾性研究。结果保留NAC组中位随访时间为48个月,传统改良根治组为50个月。保留NAC组5年局部区域复发率为5.0%,传统改良根治组为7.5%,两者比较差异无统计学意义(P=0.673)。保留NAC组5年远处转移率为10.0%,传统改良根治组为7.5%,两者比较差异无统计学意义(P=0.557)。保留NAC组和传统改良根治组5年总生存率分别为96.0%和98.2%,差异无统计学意义(P=0.589);两组5年无瘤生存率分别为91.7%和92.3%,差异无统计学意义(P=0.612)。结论严格把握适应症基础上,保留NAC改良根治术对早期乳腺癌的疗效与传统改良根治术疗效相近,但可达到患者乳房重建的美容效果和提高患者术后生活质量。
Objective To study the efficacy of NAC-preserving modified radical operation on early stage breast cancer.Methods The patients who received NAC-preserving modified radical operation（40 patients）and conventional modified radical operation（40 patients）were matched for retrospective analysis.Results Median follow-up time was 48 months in NAC-preserving operation group and 50 months in conventional operation group.The 5-year occurrence rate of loco-regional recurrence was 5.0% in NAC-preserving operation group and 7.5% in conventional operation group（P=0.673）.The 5-year occurrence rate of distant metastasis was 10.0% in NAC-preserving operation group and 7.0% in conventional operation group（P=0.557）.The 5-year OS rates were 96.0% in NAC-preserving operation group and 98.2% in conventional operation group（P=0.589）.The 5-year DFS rates were 91.7% in NAC-preserving operation group and 92.3% in conventional operation group（P=0.612）.Conclusion Modified NAC-preserving radical operation has similar effect on early stage breast cancer as conventional modified radical operation based on careful consideration of the indications.Modified NAC-preserving radical operation gives patients better cosmetic appearance after restitution and better quality of life.
出处
《实用癌症杂志》
2013年第3期256-259,共4页
The Practical Journal of Cancer
基金
广东省韶关市医药卫生科研计划项目(编号:Y11020)
关键词
乳腺癌
改良根治术
乳头乳晕复合体
Breast canceer
Modified radical operation
Nipple-areolar complex
