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长链非编码RNA在膀胱癌中的研究进展 被引量：4

Research Progress of long non-coding rna in bladder carcinoma
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摘要 近几年研究发现长链非编码RNA(long non-coding RNA,lncRNA)在肿瘤的发生发展过程中发挥着重要的作用。lncRNA是一类转录本长度大于200个核苷酸不编码蛋白质的RNA分子,在正常细胞与肿瘤细胞的基因表达调节中起着重要作用,lncRNA与肿瘤细胞的增殖、浸润、转移和复发密切相关。在膀胱癌中lncRNA可以作为检测指标及预后因子,有望成为疾病治疗的新靶点。本文对lncRNA在膀胱癌中的研究进展进行综述,探讨lncRNA在调控膀胱癌发生发展中的作用机制。 Recently, several studies have found that long non-coding RNA （lncRNA） plays an important role in the progress of cancer development, lncRNAs are longer than 200 bp and without protein coding capacity, which are in- volved in important gene expression regulation at normal and cancer cells, lncRNAs are closely related to tumor cell pro- liferation, invasion, metastasis and recurrence. IneRNAs may be a potential novel therapeutic target as a diagnostic mark- er and prognostic factor in bladder carcinoma. This paper summarized the research progress about lncRNAs in bladder carcinoma to explore the mechanism of the regulation of bladder carcinoma development by lneRNAs.
作者 金桂花 王丽娟 朱青 白娥 周侠 李萌
机构地区 西安交通大学医学院第一附属医院肿瘤内科
出处 《西部医学》 2013年第9期1418-1421,共4页 Medical Journal of West China
基金 国家自然科学基金资助项目(81272200 81072117)
关键词 长链非编码RNA 膀胱癌 研究进展 Long non-coding RNA Bladder carcinoma Research progress
分类号 R329.26 [医药卫生—人体解剖和组织胚胎学] R737.14 [医药卫生—肿瘤]
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参考文献27

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同被引文献47

  • 1连贵勇,王铭辉,姜明,罗铭,王浩然.长链非编码RNA HOTAIR在食管鳞状细胞癌中的表达及意义[J].岭南现代临床外科,2012,12(6):407-409. 被引量：3
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  • 8He W, Cai Q, Sun F, et al. line-UI3C;1 physically associates with poly- comb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer[J]. Biochim Biophys Acta,2013,1832(10) : 1528-1537.
  • 9Gupta RA,Shan N,Wang KC,et al. Long non-coding RNA HO TAIR reprograms ehromatin state to promote cancer metastasis [J]. Nature,2010,464(7291) : 1071-1076.
  • 10王宝森,邢金春,郑嘉欣.UCA1在膀胱癌中的表达及临床意义[J].中国现代医生,2010,48(4):16-18. 被引量：13

引证文献4

二级引证文献10

西部医学
2013年 第9期

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