摘要
目的探讨三维适形低分割放疗联合吉非替尼治疗老年非小细胞肺癌（NSCLC）的疗效及不良反应。方法对27例老年NSCLC患者实施低分割放疗联合吉非替尼治疗，分割方案：2．5Gy／d、5f／w，总剂量：35～55Gy；口服吉非替尼250mg，1次／日。结果3个月近期有效率（CR＋PR）66．7％，1年生存率63．OVoo；放射性肺炎发生率25．9％，放射性食管炎发生率29．6％，皮疹发生率37．O％，腹泻发生率22．2％。结论三维适形低分割放疗联合吉非替尼治疗安全有效，不良反应未见明显增加。
Objective To investigate the efficacy and toxicity of three-dimensional eonformal radiotherapy com- bined with gefitinib in elderly NSCLC. Methods 27 eases of elderly NSCLC patients were analyzed. Results The effica- cy rate was 66, 7%. 1-year survival rates were 63.0%, The incidence of radiation pneumonitis was 25.9%. The inci- dence of radiation esophagitis was 29.6%. The incidence of rash was 37.0% ,and the incidence of diarrhea was 22.2%. Conclusion The three-dimensional eonformal Hypofraetionated high-dose radiotherapy combined with gefitinib for elderly non-small cell lung cancer is safely and definitely,
出处
《西部医学》
2013年第9期1312-1315,共4页
Medical Journal of West China
基金
陕西省自然科学基金资助项目(2012JM4008)
关键词
老年非小细胞肺癌
吉非替尼
低分割
Elderly Non-small cell lung eancer Gefitinib Hypofractionated high-dose
