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慢性心力衰竭患者血N端B型脑钠肽、β2微球蛋白的临床意义及相关性研究 被引量:11

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摘要 目的观察慢性心力衰竭患者血浆N端B型脑钠肽(NT-proBNP)、β2微球蛋白(β2-MG)的临床意义及其相关性。方法将120例慢性心力衰竭患者按纽约心脏病协会(NYHA)心功能分级方法分为3组:心功能Ⅱ级组、Ⅲ级组、Ⅳ级组,每组40例,测定3组患者血NT-proBNP、β2-MG、尿素氮(BUN)、肌酐(Cr),并进行统计学分析。结果 3组NT-proBNP水平差异有统计学意义(P<0.01),且随心力衰竭程度加重而增加;心功能Ⅳ级组β2-MG水平高于心功能Ⅱ、Ⅲ级组(P<0.01),心功能Ⅱ、Ⅲ级组β2-MG水平差异无统计学意义(P>0.05)。NT-proBNP与β2-MG呈高度正相关(r=0.855,P<0.01)。各组BUN、Cr差异无统计学意义(P>0.05)。结论 NT-proBNP能准确评估心功能,且心衰越重早期肾损害越重。
机构地区 天津市第四医院
出处 《天津医药》 CAS 北大核心 2013年第9期919-920,共2页 Tianjin Medical Journal
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