摘要
目的 探索一氧化氮合成酶 (NOS)抑制剂对断裂周围神经再生的影响。方法 用 SD雄性大鼠 24只。在距梨状肌下缘 1cm处切断坐骨神经，远断端去除 4mm长，取硅胶管桥接两神经断端，并使其相距 4mm，随机分成硅胶管和腹腔注射两组。一组其右侧注入 10mg/kg亚硝基左旋精氨酸甲酯 (L-NAME)，左侧注入等量生理盐水作对照。另组用同等剂量 L-NAME改为腹腔注射 10d。每组分成二半，分别于术后 1、 2月取材，作组织学检测。结果 发现 L-NAME对周围神经的再生有明显的促进作用，而局部注射药较腹腔注射给药神经再生优。结论 L-NAME能促进周围神经再生。
Objective To obtain the effects of the L-NAME therapy in peripheral nerve regeneration .Methods Twenty four SD male rats were used in this study.Their bilateral sciatic nerves were cut off at 1cm from the site under the musculus piriformis then distant end of the nerve were cut off of 4mm.The two ends of nerve were bridged by silicone chamber.They were divided into two groups (silicone chamber injection abdomenal cavity injection )at random .Then each of them was divided into the right inject L-NAME one and left inject NSL one in the group of the silicome chamber injection.Histologic examination was performed.Result L NAME can improve peripheral nerve regeneration .Conclusion L NAME can improve peripheral nerve regeneration.
出处
《现代康复》
CSCD
2000年第11期1670-1671,共2页
Modern Rehabilitation
基金
卫生部课题! (94-1-322)
关键词
亚硝基左旋精氨酸甲酯
周围神经
再生
Nitro L arginine methyl ester
perpheral nerve
regeneration$
