摘要
Pokemon蛋白（也被称为LRF、ZBTB7、OCZF、FBI-1）,即POK红系髓性致癌因子（erythroid ontogenic factor）,是转录抑制因子POK家族的一员,现已被确认为原癌基因。微小核糖核酸microRNA（miRNA）是近年来研究最活跃的细胞调控因子,miRNA是一种22~25个核苷酸之间的非编码RNA,能在转录和翻译水平上调控基因表达,它们都在结肠癌中发挥作用。文章对Pokemon、miRNA调控结肠癌发生发展的研究进行综述。
POK erythroid myeloid ontogenic factor （Pokemon）,also called as LRF,ZBTB7, OCZF or FBI-1 ,has been identified as an oncogene. MicroRNAs （miRNAs） are 22~25 nu- cleotides long,non-coding RNAs,which could regulate transcriptional and translational gene expression. Both Pokemon and miRNAs play very important roles in colon cancer. This paper reviews on Pokemon and miRNA regulating carcinogensis and progress for colon cancer.
出处
《肿瘤学杂志》
CAS
2013年第8期644-648,共5页
Journal of Chinese Oncology
