摘要
目的 探讨血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)表达与血管网织细胞瘤病理发生的关系。方法 用免疫组化S-P法分析43例血管网织细胞瘤和30例正常脑组织中VEGF、bFGF蛋白的表达。结果 ①43例血管网织织细胞瘤中VEGF表达阳性者42例,其中强阳性者26例;bFGF表达阳性者8例,其中强阳性者2例;二者阳性率相比,差异有显著性(P<0.01)。②血管网织细胞瘤与正常脑组织相比,在VEGF表达上差异有显著性(P<0.01),在bFGF表达上差异无显著性(P>0.05)。结论 VEGF蛋白高表达可能是血管网织细胞瘤高度血管化和囊性变的直接机制。
Objective To investigate the relationship between the expression of VEGF or bFGF and the pathogenesis of an-gioreticuoma. Method The samples of 43 angioreticulomas and normal cerebral tissues from 30 cases were examined for VEGF and bFGF protein expression after S-P immunohistochemical staining. Results The positive VEGF staining were found in 42 of the 43 an-gioreticuloma samples and among them 26 were strongly positive. As for bFGF, positive staining was shown in 8 cases including 2 strongly positive cases. The positive rate of VEGF was obviously higher than that of bFGG ( P<0.01); The expression level of VEGF in angioreticulomas was significantly higher than that in the normal cerebral tissues ( P<0.01); There was no significant difference in bFGF expression between them (P> 0.05) . Conclusions VEGF probably have close relationship with vascularization and cytogene-sis of angioretieuloma.
出处
《中国临床神经外科杂志》
2000年第4期229-231,共3页
Chinese Journal of Clinical Neurosurgery
