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视前区调控因子-2的研究进展 被引量：1

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摘要 视前区调控因子-2（preopticregulatoryfactor-2。porf-2）是首先在中枢神经系统中发现的生长调控因子，最初在去势的雄性大鼠下丘脑视前区被发现,其mRNA的表达水平和年龄、性别以及激素水平有关，并具有区域特殊性。随后porf-2在人体的各个组织器官如：下丘脑、睾丸、肾上腺、胎盘和前列腺等不断被发现。
作者 黄国辉 黄朝帅 冯东福
机构地区 上海交通大学医学院附属第三人民医院神经外科.上海交通大学医学院创伤医学研究所
出处 《实用医学杂志》 CAS 北大核心 2013年第17期2913-2915,共3页 The Journal of Practical Medicine
基金 国家自然科学基金项目(编号:81171796)
关键词 下丘脑视前区 生长调控因子 中枢神经系统 激素水平 雄性大鼠 mRNA 组织器官 肾上腺
分类号 R363 [医药卫生—病理学]
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参考文献29

  • 1Nowak F V. Cloning of two hypothalamic cDNAs encodingho tissue- specific transcript s in the preoptic area and testis[J]. Mol Endocrinol, 1990,4(8) : 1205-1210.
  • 2Nowak F V. Modulation of preoptic regulatory factor-2 (porf-2) mRNAs by castration and hypophysectomy [J]. Endocrine, 1997,6( 1 ) : 57-63.
  • 3Nowak F V. Expression and characterization of the preoptic regulatory factor-1 and -2 peptides [J]. Regal Pept, 2003,115 (3) : 179-185.
  • 4Peck J, Douglas G, Wu C H, et al. Human RGAP domain-containing proteins: structure, function and evolutionary relationships [J] FEBS.Lett, 2002,528 (1-3) : 27-34.
  • 5Wu L, Pan L, Wei Z, et al. Structure of MyTH4-FERM domains in myosin Vlla tail bound to cargo [J]. Science, 2011,331 (6018) :757-760.
  • 6Nowak F V, Torres G, Golden J, et al. Expression of the preoptic regulatory factor-1 and -2 genes in rat testis. Developmental and hormonal regulation [J]. Endocrine, 1997,6 ( 1 ) :65-72.
  • 7Nowak F V, Gore A C. Perinatal developmental changes in expression of the neuropeptide genes preoptic regulatory factor- 1 and factor-2, neuropeptide Y and GnRH in rat hypothalamus [J]. J Neuroendocrinol, 1999,11 (12) :951-958.
  • 8Nowak F V, Torres G E, Hu S B. Differential gene expression response to gonadal hormones by preoptic regulatory factors-1 and -2 in the female rat brain [J]. Neuroendocrinology, 1999,69 (3):191-201.
  • 9Hu S B, Nowak F V. Regional distinction in age-related changes of preoptic regulatory factor- 1 and preoptic regulatory factor-2 mRNA expression in the rat brain [J]. Mol Cell Neurosci, 1994,5 (4) : 376-381.
  • 10Hu S B, Nowak F V. Sex-specific changes in preoptic regulatory factor- 1 and preoptic regulatory factor-2 mRNA expression in the rat brain during development [J]. Endocrine, 1995,3(6) :421-424.

二级参考文献78

共引文献6

同被引文献13

  • 1Nowak FV. Cloning of two hypothalamic cDNAs encoding tissue- specific transcripts in the preoptic area and testis [ J ]. Mol Endocrinol, 1990, 4(8) : 1205 -1210.
  • 2Nowak FV, Tortes G, Golden 3, et ah Expression of the preoptic regulatory factor-1 and -2 genes in rat testis. Developmental and hormonal regulation[J]. Endocrine, 1997, 6( 1 ) : 65 -72.
  • 3Wu L, Pan L, Wet Z, et al. Structure of MyTH4-FERbl domains in myosin VIIa tail bound to cargo[ J]. Science, 2011, 331 (6018) : 757 - 760.
  • 4Peck J, Douglas G 4th, Wu C H, et al. Human RhoGAP domain- containing proteins: structure, function and evolutionary relation- ships[J]. FEBS Lett, 2002, 528 (1-3): 27-34.
  • 5Lundstrm A, Gallio M, Ertglund C, et al. Vilse, a conserved Rac/ Cdc42 GAP mediating Robo repulsion in tracheal cells and axons [J]. Genes Dev, 2004, 18(17): 2161 -2171.
  • 6Hu H, Li M, Labrador JP, et al. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion[ J]. Proc Natl Acad Sci U S A, 2005, 102(12) : 4613 -4618.
  • 7Lim J, Ritt DA, Zhou M, et al. The CNK2 scaffold interacts with vilse and modulates rac cycling during spine morphogenesis in hippocampal neurons [ J]. Curr Biol, 2014, 24 (7) : 786 - 792.
  • 8Nowak FV. Modulation of preoptie regulatory factor-2 (Porf-2) mRNAs by castration and hypophysectomy[ J]. Endocrine, 1997, 6 (1): 57 -63.
  • 9Nowak FV, Gore AC. Perinatal developmental changes in expression of the neuropeptide genes preoptic regulatory factor-1 and factor-2, neuropeptide Y and GnRI'I in rat hypothalamus [ J ]. J Neuroendocrinol, 1999, 11(12) : 951 -958.
  • 10Nowak FV, Torres GE, Hu SB. Differential gene expression response to gonadal hormones by preoptic regulatory factors-1 and -2 in the female rat brain [ J ]. Neuroendoerinology, 1999, 69 ( 3 ) : 191 - 201.

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实用医学杂志
2013年 第17期

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