摘要
目的 :探讨α 平滑肌肌动蛋白 (α SMA)在系膜细胞表型转化中的变化及临床意义。方法 :取 87例肾小球肾炎的肾穿刺组织作免疫组化检查 ,检测α SMA的表达程度。结果 :α SMA的表达程度与系膜细胞增生程度成正比。结论 :α SMA阳性表达作为系膜细胞受损激活和表型转化的标志 ,可反映系膜细胞的机能状态和增殖情况。
Objective:To study the variation and clinical significance of alpha smooth muscle actin (α SMA)in the phenotypic transformation of mesangial cells.Method:Punctured tissues from 87 glomerulonephritis patients were studied using immunohistochemical assay.Result:The expression level of α SMA was directly related to the proliferation level of mesangial cells.Conclusion:As a mark of mesangial cell injury activation and phenotypic transformation,the positive expression of α SMA could be the reflection of the functional and proliferative status of mesangial cells.
出处
《右江医学》
2000年第4期239-241,共3页
Chinese Youjiang Medical Journal
关键词
肾小球肾炎
系膜细胞
表型转化
Α-SMA
系膜增生
glomerulonephritis
mesangial cell
phenotypic transformation
α SMA
mesangial proliferation
