摘要
目的 探讨E Cadherin在膀胱移行细胞癌中表达的临床意义。 方法 采用免疫组织化学方法 ,检测 6 3例膀胱移行细胞癌石蜡标本E Cadherin表达情况。 结果 6 3例膀胱癌组织标本中E Cadherin表达异常者 42例 (6 7% ) ,异常表达率与膀胱癌的病理分期、分级 ,肿瘤复发和生存率间的差别均有显著性意义。 结论 E Cadherin的异常表达与膀胱癌的恶性程度及复发密切相关 ,可作为判定肿瘤预后和复发的分子生物学指标。
Objective To assess the relation and clinical significance between E-Cadherin expression and the biological behavior of bladder transitional cell carcinoma. Methods Immunohistochemical method was used to detect E-Cadherin in 63 cases of bladder transitional cell carcinoma and 6 normal bladder biopsies as controls.The results were analyzed,and combinated with clinical and pathological data. Results Normal E-Cadherin expression was found in all the 6 normal bladder membranous tissues.Abnormal E-Cadherin expression was found in 42 cases of bladder cancer (66.7%) indicating that abnormal E-Cadherin expression correlates with both increased grade,stage,high recurrence and poor survival. Conclusions E-Cadherin expression is closely related to the malignant progression of bladder cancer.The detect of E-Cadherin expression is helpful in predicting the biological behavior of bladder transitional cell carcinoma.Therefore,E-Cadherin could be used as an useful molecular marker for predicting the progression,recurrence and prognosis of bladder transitional cell carcinoma.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2000年第9期545-546,共2页
Chinese Journal of Urology
