摘要
目的:观察磷霉素钠联合头孢哌酮钠/舒巴坦钠治疗下呼吸道感染的疗效与安全性。方法:79例下呼吸道感染住(?)患者按入院顺序分为两组,观察组给予磷霉素钠注射剂4.0 g,ivd qd,给药后1h给予头孢哌酮钠/舒巴坦钠注射剂2.0 g,ivd bid;对照组单独应用头孢哌酮钠/舒巴坦钠注射剂2.0 g,ivd bid。两组疗程均为7～14 d,比较两组有效率、细菌清除率及不良反应情况。结果:观察组有效率和细菌清除率分别为92.50%和85.71%,对照组分别为74.35%和62.96%,两组比较,差异均有统计学意义(P<0.05);两组不良反应发生率分别为2.50%和2.56%,差异无统计学意义(P>0.05)。结论:磷霉素钠联合头孢哌酮钠/舒巴坦钠治疗下呼吸道感染,疗效优于单用头孢哌酮钠/舒巴坦钠,且安全性良好,值得临床推广应用。
Objective：To observe the curative effect and security of fosfomycin sodium injection combined with cefoperazone sodium and sulbactam sodium injection in treating lower respiratory tract infection. Methods：79 cases of lower respiratory tract infection were divided into two groups randomly. The treatment group were given fosfomycin sodium injection 4.0g by ivd within 1-2h. 1 hours after administration, cefoperazone sodium and sulbactam sodium injection were given 2.0g by ivd within 30-60min,2 times per day, and the period of treatment was 7-14d. The controlled group were given cef- operazone sodium and sulbactam sodium injection 2.0g by ivd, 2 times per day, the period of treatment was 7-14d. The efficacy, bacterial clearance rate and adverse reaction of the two groups were observed. Results：The effective rates and bacteria elimination rates of the treatment groups were 92.5% and 85.7% respectively and 74.35%, and 62.96% respectively in the controlled group. Significant differences were found through comparison between the two groups（P〈0.05）; The incidence of adverse reactions were 2.50% and 2.56% respectively, No significant differences were found between the two groups （P〉0.05）. Conclusion：The curative effect of fosfomycin sodium injection combined with cefoperazone sodium and sulbactam sodium injection in treating lower respiratory tract infection was better than that of single cefoperazone sodium and sulbactam sodium injection, and the good security was worthy of clinical application.
出处
《药物流行病学杂志》
CAS
2013年第8期413-414,429,共3页
Chinese Journal of Pharmacoepidemiology
关键词
磷霉素钠
头孢哌酮钠
舒巴坦钠
下呼吸道感染
疗效
Fosfomycin Sodium
Cefoperazone Sodium and Sulbactam Sodium
Lower respiratory tract infection
Curative effect
