摘要
目的:探讨急性缺血性脑卒中患者颈动脉粥样硬化与D-二聚体水平的关系。方法:回顾分析115例急性缺血性脑卒中患者(A组)、50例无缺血性脑卒中的单纯性颈动脉粥样硬化患者(B组)、50例健康体检者(C组)的颈动脉内-中膜厚度(IMT)以及血浆D-二聚体水平,其中IMT测定采用彩色多普勒超声扫描,D-二聚体测定采用透射免疫比浊法。结果:①3组个体的颈动脉IMT、血浆D-二聚体差异有统计学意义(P<0.05),A组患者的颈动脉IMT、血浆D-二聚体显著高于B组(P<0.05),B组患者的颈动脉IMT、血浆D-二聚体显著高于C组(P<0.05)。②缺血性脑卒中组患者的颈动脉IMT与血浆D-二聚体呈正相关(r=0.732,P<0.05)。结论:随着颈动脉粥样硬化程度的加重,急性缺血性脑卒中患者的血浆D-二聚体水平逐渐升高,D-二聚体可以作为反映颈动脉粥样硬化严重程度的指标之一。
Objective：To explore the relationship between carotid atherosclerosis and D-dimer levels in patients with acute ischemic stroke.Methods：The carotid intima-media thickness（IMT） and plasma D-dimer levels of 115 cases of acute ischemic stroke（Group A）,50 cases of simple carotid atherosclerosis without ischemic stroke（Group B） and 50 cases of healthy subjects（Group C） were analysed retrospectively,which were measured by color Doppler ultrasound scanner and immunological transmission turbidimetry,respectively.Results：①There were significantly differences in the carotid IMT and plasma D-dimer among the 3 groups（P0.05）.The carotid IMT and plasma D-dimer of Group A were significantly higher than those of Group B（P0.05）,which were significantly higher than those of Group C（P0.05）.②The carotid IMT was positively correlated with plasma D-dimer in patients with acute ischemic stroke（r=0.732,P0.05）.Conclusion：The more serious the carotid atherosclerosis,the higher the plasma D-dimer,and the plasma D-dimer may be considered as one of indicators for carotid atherosclerosis severity.
出处
《中国医药导刊》
2013年第5期872-872,875,共2页
Chinese Journal of Medicinal Guide
